Degrell I, Niklasson F
Department of Neurology and Psychiatry, University of Debrecen Medical School, Hungary.
Arch Gerontol Geriatr. 1988 Jun;7(2):173-8. doi: 10.1016/0167-4943(88)90029-5.
Concentrations of hypoxanthine, xanthine, uric acid and creatinine were measured in CSF of patients suffering form presenile and senile dementia of Alzheimer type (PDAT, SDAT) and multi infarct dementia (MID) and in a reference group of young neurotic patients. There was no difference in hypoxanthine concentration, but there was a marked elevation of xanthine concentration in each dementia group, independent of the type of dementia. There was a significant elevation of uric acid in SDAT and MID but not in PDAT. The concentration of uric acid was higher in MID than in SDAT. There was a higher level of creatinine in the dementia groups, but no difference was seen among the dementia groups. These results are discussed in order to better interpret the etiology and the differentiated diagnosis of the types of dementia.
测定了患有早老性和老年性阿尔茨海默型痴呆（PDAT、SDAT）以及多发梗死性痴呆（MID）患者的脑脊液中次黄嘌呤、黄嘌呤、尿酸和肌酐的浓度，并与一组年轻神经症患者作为参照组进行对比。次黄嘌呤浓度无差异，但各痴呆组中黄嘌呤浓度均显著升高，与痴呆类型无关。SDAT和MID中尿酸显著升高，而PDAT中未升高。MID中的尿酸浓度高于SDAT。痴呆组中肌酐水平较高，但各痴呆组之间无差异。对这些结果进行了讨论，以便更好地解释痴呆类型的病因和鉴别诊断。
