Degrell I, Hellsing K, Nagy E, Niklasson F
Department of Neurology and Psychiatry, University Medical School of Debrecen, Hungary.
Arch Gerontol Geriatr. 1989 Sep-Oct;9(2):123-35. doi: 10.1016/0167-4943(89)90033-2.
Free amino acid levels were measured in cerebrospinal fluid (CSF) from demented patients (D, n = 30) suffering from presenile and senile dementia of Alzheimer type (PDAT, n = 7; SDAT, n = 9), multi-infarct dementia (MID, n = 14) and a reference sample group consisting of young neurotic patients (R, n = 16). Comparing the amino acid levels in the dementia subgroups, significantly higher alanine, methionine, phenylalanine and tyrosine levels were found both in MID and SDAT vs. PDAT. No difference was seen between SDAT and MID. Compared to the reference sample group, higher glycine levels were found in each dementia subgroup; higher alanine, methionine and ornithine levels in MID, and SDAT; and higher phenylalanine levels in MID. In PDAT the level of tyrosine was lower. Coefficients of correlation were calculated between amino acid levels and age, and the findings in the reference sample groups were divergent from those observed in dementia. The differences observed are discussed in terms of amino acid, carbohydrate and neurotransmitter metabolism.
对患有早老性和老年性阿尔茨海默型痴呆（早发性阿尔茨海默病，7例；晚发性阿尔茨海默病，9例）、多发梗死性痴呆（14例）的痴呆患者（D组，n = 30）以及由年轻神经症患者组成的参考样本组（R组，n = 16）的脑脊液（CSF）中的游离氨基酸水平进行了测量。比较痴呆亚组中的氨基酸水平，发现多发梗死性痴呆组和晚发性阿尔茨海默病组中的丙氨酸、蛋氨酸、苯丙氨酸和酪氨酸水平均显著高于早发性阿尔茨海默病组。晚发性阿尔茨海默病组和多发梗死性痴呆组之间未发现差异。与参考样本组相比，各痴呆亚组中的甘氨酸水平均较高；多发梗死性痴呆组和晚发性阿尔茨海默病组中的丙氨酸、蛋氨酸和鸟氨酸水平较高；多发梗死性痴呆组中的苯丙氨酸水平较高。早发性阿尔茨海默病组中的酪氨酸水平较低。计算了氨基酸水平与年龄之间的相关系数，参考样本组中的结果与痴呆组中观察到的结果不同。从氨基酸、碳水化合物和神经递质代谢方面对观察到的差异进行了讨论。
