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机器人辅助肾手术治疗合并下腔静脉血栓的肾细胞癌

Robotic renal surgery for renal cell carcinoma with inferior vena cava thrombus.

作者信息

Masic Selma, Smaldone Marc C

机构信息

Fox Chase Cancer Center, Philadelphia, PA, USA.

出版信息

Transl Androl Urol. 2021 May;10(5):2195-2198. doi: 10.21037/tau.2019.06.15.

DOI:10.21037/tau.2019.06.15
PMID:34159102
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8185684/
Abstract

Surgical management of renal cell carcinoma (RCC) with inferior vena cava (IVC) thrombus is inherently complex, posing challenges for even the most experienced urologists. Until the mid-2000s, nephrectomy with IVC thrombectomy was exclusively performed using variations of the open technique initially described decades earlier, but since then several institutions have reported their robotic experiences. Robotic IVC thrombectomy was initially reported for level I and II thrombi, and more recently in higher-lever III thrombi. In general, the robotic approach is associated with less blood loss and shorter hospital stays compared to the open approach, low rates of open conversion in reported cases, relatively low rates of high-grade complications, and favorable overall survival on short-term follow-up in limited cohorts. Operative times are longer, costs are significantly higher, and left-sided tumors always require intraoperative repositioning and usually require preoperative embolization. To date, criteria for patient selection or open conversion have not been defined, and long-term oncologic outcomes are lacking. While the early published robotic experience demonstrates feasibility and safety in carefully selected patients, longer-term follow-up remains necessary. Patient selection, indications for open conversion, logistics of conversion particularly in emergent settings, necessity and safety of preoperative embolization, the value proposition, and long-term oncologic outcomes must all be clearly defined before this approach is widely adopted.

摘要

伴有下腔静脉(IVC)血栓形成的肾细胞癌(RCC)的外科治疗本质上很复杂,即使对最有经验的泌尿外科医生来说也颇具挑战。直到21世纪中叶,IVC血栓切除术联合肾切除术一直完全采用几十年前最初描述的开放技术的变体来进行,但从那时起,已有几家机构报告了他们的机器人手术经验。机器人IVC血栓切除术最初报道用于I级和II级血栓,最近也用于更高水平的III级血栓。总体而言,与开放手术相比,机器人手术方法出血量更少、住院时间更短,报告病例中的开放手术转换率低,高级别并发症发生率相对较低,在有限队列的短期随访中总体生存率良好。手术时间更长,成本显著更高,左侧肿瘤总是需要术中重新定位,通常还需要术前栓塞。迄今为止,尚未确定患者选择或开放手术转换的标准,且缺乏长期肿瘤学结果。虽然早期发表的机器人手术经验证明了在精心挑选的患者中的可行性和安全性,但仍需要长期随访。在这种方法被广泛采用之前,必须明确患者选择、开放手术转换的指征、特别是在紧急情况下的转换流程、术前栓塞的必要性和安全性、价值主张以及长期肿瘤学结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf96/8185684/130990597919/tau-10-05-2195-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf96/8185684/633b2b942e16/tau-10-05-2195-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf96/8185684/130990597919/tau-10-05-2195-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf96/8185684/633b2b942e16/tau-10-05-2195-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf96/8185684/130990597919/tau-10-05-2195-f2.jpg

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