葡萄膜黑色素瘤的钴板放疗与眼球摘除术：生存率比较
Cobalt plaque versus enucleation for uveal melanoma: comparison of survival rates.
作者信息
Adams K S, Abramson D H, Ellsworth R M, Haik B G, Bedford M, Packer S, Seddon J, Albert D, Polivogianis L
机构信息
Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital, New York, New York 10021.
出版信息
Br J Ophthalmol. 1988 Jul;72(7):494-7. doi: 10.1136/bjo.72.7.494.
Abstract
Two hundred and twenty-three patients treated by cobalt plaque for uveal melanoma were compared with 416 patients treated by enucleation for uveal melanoma in terms of patient survival. The median follow-up time for the patients treated by cobalt plaque was 4.3 years. Kaplan-Meier survival curves were calculated up to five years following treatment based on time to tumour-related deaths. Cox's proportional hazards multivariate analysis was performed to determine which variables were related to melanoma-related deaths while controlling for age, size, and location of the tumours. Statistically significant predictive factors were location of tumour and largest tumour dimension. There was not a statistically significant difference in survival between patients treated by cobalt plaque and those treated by enucleation.
摘要
在患者生存率方面，对223例接受钴板治疗的葡萄膜黑色素瘤患者与416例接受眼球摘除术治疗的葡萄膜黑色素瘤患者进行了比较。接受钴板治疗的患者中位随访时间为4.3年。根据肿瘤相关死亡时间计算治疗后长达五年的Kaplan-Meier生存曲线。进行了Cox比例风险多变量分析，以确定在控制肿瘤的年龄、大小和位置的同时，哪些变量与黑色素瘤相关死亡有关。具有统计学意义的预测因素是肿瘤位置和最大肿瘤尺寸。接受钴板治疗的患者与接受眼球摘除术治疗的患者在生存率方面没有统计学上的显著差异。
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