Cielo Christopher M, Keenan Brendan T, Wiemken Andrew, Tapia Ignacio E, Kelly Andrea, Schwab Richard J
Division of Pulmonary & Sleep Medicine, Children's Hospital of Philadelphia.
University of Pennsylvania, Philadelphia, PA.
Sleep. 2021 Nov 12;44(11). doi: 10.1093/sleep/zsab158.
Increased neck circumference, a surrogate for the neck fat that can narrow the upper airway in obese individuals, is a risk factor for obstructive sleep apnea syndrome (OSAS) in adults, but the association between neck fat and OSAS in adolescent males and females is unknown. We hypothesized that obese adolescents with OSAS have more neck fat than controls, females more neck fat than males, and that neck fat correlates with obesity and OSAS severity.
Obese adolescents with OSAS and obese and normal-weight controls underwent upper airway magnetic resonance imaging, polysomnography, and anthropometrics, including neck circumference measurement. Intra-neck and subcutaneous neck fat measurements were manually segmented and compared among the three groups using ANOVA and between males and females using t-tests. The relationship between polysomnographic parameters and neck fat measurements was assessed in adolescents with OSAS using Pearson correlations.
One-hundred nineteen adolescents (38 females) were studied: 39 obese with OSAS, 34 obese controls, and 46 normal-weight controls. Neck fat was not greater in adolescents with OSAS compared to obese controls (p=0.35), and neck fat volume was not related to OSAS severity (p = 0.36). However, obese adolescents had more neck fat than normal-weight controls (p < 0.001), and neck fat volume correlated with neck circumference (r = 0.53, p < 0.001). Females had significantly greater cross-sectional neck fat than males (p < 0.001).
While neck fat is associated with obesity and neck circumference in adolescents and is greater in females versus males, it does not appear to correlate with presence and severity of OSAS.
颈围增加是颈部脂肪的一个替代指标，在肥胖个体中可使上气道变窄，是成人阻塞性睡眠呼吸暂停综合征（OSAS）的一个危险因素，但青少年男性和女性颈部脂肪与OSAS之间的关联尚不清楚。我们假设患有OSAS的肥胖青少年比对照组有更多的颈部脂肪，女性比男性有更多的颈部脂肪，并且颈部脂肪与肥胖和OSAS严重程度相关。
患有OSAS的肥胖青少年以及肥胖和体重正常的对照组接受上气道磁共振成像、多导睡眠图检查和人体测量，包括颈围测量。对颈部内脂肪和颈部皮下脂肪测量值进行手动分割，并使用方差分析在三组之间进行比较，使用t检验在男性和女性之间进行比较。使用Pearson相关性分析评估患有OSAS的青少年多导睡眠图参数与颈部脂肪测量值之间的关系。
共研究了119名青少年（38名女性）：39名患有OSAS的肥胖青少年、34名肥胖对照组和4名体重正常的对照组。与肥胖对照组相比，患有OSAS的青少年颈部脂肪并不更多（p=0.35），并且颈部脂肪体积与OSAS严重程度无关（p = 0.36）。然而，肥胖青少年比体重正常的对照组有更多的颈部脂肪（p < 0.001），并且颈部脂肪体积与颈围相关（r = 0.53，p < 0.001）。女性的颈部横断面脂肪明显多于男性（p < 0.001）。
虽然颈部脂肪与青少年的肥胖和颈围相关，且女性比男性更多，但它似乎与OSAS的存在和严重程度无关。
