Acritidis N C, Andonopoulos A P, Galanopoulou V, Drosos A A, Constantopoulos S H
Department of Medicine, School of Medicine, University of Ioannina, Greece.
Clin Rheumatol. 1988 Jun;7(2):231-6. doi: 10.1007/BF02204460.
The pulmonary function of 26 nonsmoking patients with giant cell arteritis (GCA) and/or polymyalgia rheumatica (PMR) was evaluated and the results were compared with those of 28 age and sex matched nonsmoking controls. Normal function was observed in 30.8% of the patients and 50% of the controls (p = non significant). Isolated small airways disease (SAD) was detected in a high percentage of the patients (46.2%), but not significantly different from that of the controls (50%). Its clinical significance remains to be answered. Obstructive, restrictive and diffuse interstitial lung disease (DILD) was seen in one, three and two patients respectively, but was absent in the control population. All the patients had a normal chest radiograph and were asymptomatic, except for three. Two of them had normal respiratory function and one DILD. It is speculated that DILD and restrictive disease, seen only in patients with biopsy proven GCA, may be related to the underlying process.
对26例非吸烟的巨细胞动脉炎（GCA）和/或风湿性多肌痛（PMR）患者的肺功能进行了评估，并将结果与28例年龄和性别匹配的非吸烟对照者进行了比较。30.8%的患者和50%的对照者肺功能正常（p =无显著性差异）。高比例的患者（46.2%）检测到孤立性小气道疾病（SAD），但与对照者（50%）无显著差异。其临床意义仍有待解答。分别有1例、3例和2例患者出现阻塞性、限制性和弥漫性间质性肺病（DILD），而对照人群中未出现。除3例患者外，所有患者胸部X线片均正常且无症状。其中2例呼吸功能正常，1例患有DILD。据推测，仅在经活检证实为GCA的患者中出现的DILD和限制性疾病可能与潜在病程有关。
