Fazekas-Pongor V, Fekete M, Balazs P, Árva D, Pénzes M, Tarantini S, Urbán R, Varga J T
1Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest H-1085, Hungary.
2University of Oklahoma Health Sciences Center, Department of Biochemistry and Molecular Biology, Oklahoma City, OK 73132, USA.
Physiol Int. 2021 Jun 21. doi: 10.1556/2060.2021.00017.
Chronic obstructive pulmonary disease (COPD) is the fourth most frequent disease globally, and its worldwide prevalence is projected to increase in the following decades. Health-related quality of life (HRQOL) of COPD patients depends on multiple factors.
The aim of this study was to identify the most important risk factors affecting HRQOL of COPD patients and to measure how specific clinical parameters can predict HRQOL.
A questionnaire-based cross-sectional study combined with clinical data was conducted among patients diagnosed with COPD (n = 321, 52.6% females, mean age 66.4 ± 9.5) at the National Koranyi Institute for Pulmonology, Budapest in 2019-2020. The inclusion criteria were age ≥40 years and existing COPD. Multivariate linear regression analyses were conducted on three components of the COPD-specific Saint George's Respiratory Questionnaire (SGRQ-C) and on the physical (PCS) and mental component scales (MCS) of the 36-Item Short Form Health Survey (SF-36). Multiple linear regression analysis was performed to evaluate the effects of patient and disease characteristics on COPD Assessment Test (CAT) scores.
We found that frequent exacerbations, multiple comorbidities and tobacco smoking were associated with worse HRQOL. Engaging in more frequent physical activity and better 6-minute walking distance results were associated with better HRQOL.
Our results indicate that the complex therapy of COPD should focus not only on improving lung functions and preventing exacerbation, but also on treating comorbidities, encouraging increased physical activity, and supporting smoking cessation to assure better HRQOL for patients.
慢性阻塞性肺疾病（COPD）是全球第四大常见疾病，预计在未来几十年其全球患病率还会上升。COPD患者的健康相关生活质量（HRQOL）取决于多种因素。
本研究旨在确定影响COPD患者HRQOL的最重要风险因素，并衡量特定临床参数如何预测HRQOL。
2019年至2020年期间，在布达佩斯的国家科拉尼肺科研究所，对321例被诊断为COPD的患者（女性占52.6%，平均年龄66.4±9.5岁）进行了一项基于问卷的横断面研究，并结合临床数据。纳入标准为年龄≥40岁且患有COPD。对慢性阻塞性肺疾病特异性圣乔治呼吸问卷（SGRQ-C）的三个组成部分以及36项简短健康调查问卷（SF-36）的身体（PCS）和精神组成部分量表（MCS）进行多变量线性回归分析。进行多元线性回归分析以评估患者和疾病特征对慢性阻塞性肺疾病评估测试（CAT）评分的影响。
我们发现频繁发作、多种合并症和吸烟与较差的HRQOL相关。更频繁地进行体育活动和更好的6分钟步行距离结果与更好的HRQOL相关。
我们的结果表明，COPD的综合治疗不仅应侧重于改善肺功能和预防发作，还应治疗合并症、鼓励增加体育活动并支持戒烟，以确保患者有更好的HRQOL。
