Johns Hopkins Ciccarone Center or the Prevention of Cardiovascular Disease, Baltimore, Maryland, USA.
Johns Hopkins Ciccarone Center or the Prevention of Cardiovascular Disease, Baltimore, Maryland, USA; Division of Cardiology. Vanderbilt University Medical Center, Nashville, Tennessee, USA.
J Am Coll Cardiol. 2021 Jun 29;77(25):3195-3216. doi: 10.1016/j.jacc.2021.05.006.
The MESA (Multi-Ethnic Study of Atherosclerosis) is a National Heart, Lung, and Blood Institute-sponsored prospective study aimed at studying the prevalence, progression, determinants, and prognostic significance of subclinical cardiovascular disease in a sex-balanced, multiethnic, community-dwelling U.S. cohort. MESA helped usher in an era of noninvasive evaluation of subclinical atherosclerosis presence, burden, and progression for the evaluation of atherosclerotic cardiovascular disease risk, beyond what could be predicted by traditional risk factors alone. Concepts developed in MESA have informed international patient care guidelines, providing new tools to effectively guide public health policy, population screening, and clinical decision-making. MESA is grounded in an open science model that continues to be a beacon for collaborative science. In this review, we detail the original goals of MESA, and describe how the scope of MESA has evolved over time. We highlight 10 significant MESA contributions to cardiovascular medicine, and chart the path forward for MESA in the year 2021 and beyond.
MESA（动脉粥样硬化多民族研究）是美国国立心肺血液研究所（National Heart, Lung, and Blood Institute）赞助的一项前瞻性研究，旨在研究性别均衡、多种族、社区居住的美国人群中亚临床心血管疾病的流行率、进展、决定因素和预后意义。MESA 开创了一个时代，用于评估亚临床动脉粥样硬化的存在、负担和进展，以评估动脉粥样硬化性心血管疾病风险，超越了仅通过传统风险因素可以预测的范围。MESA 中提出的概念为国际患者护理指南提供了信息，为有效指导公共卫生政策、人群筛查和临床决策提供了新工具。MESA 基于开放科学模式，继续成为合作科学的灯塔。在这篇综述中，我们详细介绍了 MESA 的最初目标，并描述了 MESA 的范围如何随着时间的推移而演变。我们强调了 MESA 对心血管医学的 10 项重大贡献，并为 2021 年及以后的 MESA 规划了前进的道路。
