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昆士兰家族队列研究:研究方案。

Queensland Family Cohort: a study protocol.

机构信息

Mother and Baby, Mater Medical Research Institute, South Brisbane, Queensland, Australia.

Faculty of Medicine, The University of Queensland, Saint Lucia, Queensland, Australia.

出版信息

BMJ Open. 2021 Jun 24;11(6):e044463. doi: 10.1136/bmjopen-2020-044463.

Abstract

INTRODUCTION

The perinatal-postnatal family environment is associated with childhood outcomes including impacts on physical and mental health and educational attainment. Family longitudinal cohort studies collect in-depth data that can capture the influence of an era on family lifestyle, mental health, chronic disease, education and financial stability to enable identification of gaps in society and provide the evidence for changes in government in policy and practice.

METHODS AND ANALYSIS

The Queensland Family Cohort (QFC) is a prospective, observational, longitudinal study that will recruit 12 500 pregnant families across the state of Queensland (QLD), Australia and intends to follow-up families and children for three decades. To identify the immediate and future health requirements of the QLD population; pregnant participants and their partners will be enrolled by 24 weeks of gestation and followed up at 24, 28 and 36 weeks of gestation, during delivery, on-ward, 6 weeks postpartum and then every 12 months where questionnaires, biological samples and physical measures will be collected from parents and children. To examine the impact of environmental exposures on families, data related to environmental pollution, household pollution and employment exposures will be linked to pregnancy and health outcomes. Where feasible, data linkage of state and federal government databases will be used to follow the participants long term. Biological samples will be stored long term for future discoveries of biomarkers of health and disease.

ETHICS AND DISSEMINATION

Ethical approval has been obtained from the Mater Research Ethics (HREC/16/MHS/113). Findings will be reported to (1) QFC participating families; (2) funding bodies, institutes and hospitals supporting the QFC; (3) federal, state and local governments to inform policy; (4) presented at local, national and international conferences and (5) disseminated by peer-review publications.

摘要

介绍

围产期-产后家庭环境与儿童结局相关,包括对身心健康和教育程度的影响。家庭纵向队列研究收集深入的数据,可以捕捉时代对家庭生活方式、心理健康、慢性疾病、教育和财务稳定的影响,从而确定社会中的差距,并为政府在政策和实践方面的变革提供证据。

方法和分析

昆士兰家庭队列(QFC)是一项前瞻性、观察性、纵向研究,将在澳大利亚昆士兰州(QLD)招募 12500 个怀孕家庭,并打算对家庭和儿童进行三十年的随访。为了确定 QLD 人口的即时和未来健康需求;怀孕参与者及其伴侣将在妊娠 24 周时被招募,并在妊娠 24、28 和 36 周、分娩时、产后 6 周以及之后每 12 个月进行随访,届时将从父母和儿童那里收集问卷、生物样本和身体测量数据。为了研究环境暴露对家庭的影响,将与妊娠和健康结果相关的数据与环境污染、家庭污染和就业暴露联系起来。在可行的情况下,将使用州和联邦政府数据库的数据链接来长期跟踪参与者。长期储存生物样本,以便未来发现健康和疾病的生物标志物。

伦理与传播

已获得 Mater 研究伦理委员会(HREC/16/MHS/113)的伦理批准。研究结果将报告给:(1)参与 QFC 的家庭;(2)为 QFC 提供支持的资助机构、研究所和医院;(3)联邦、州和地方政府以告知政策;(4)在当地、全国和国际会议上展示;(5)通过同行评审出版物传播。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d313/8231060/024e71a152e3/bmjopen-2020-044463f01.jpg

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