Association Between Helicobacter pylori and Gastric Carcinoma.

Gastric carcinoma is the third leading cause of cancer mortality worldwide. In 2018, the incidence of gastric carcinoma worldwide was over 1,000,000 new cases, with approximately 783,000 deaths. The rate of new cases is noticeably increased in Eastern Asia.  is responsible for the increased incidence of gastric cancer. In the year 2015, had an approximate prevalence of 4.4 billion positive cases worldwide, with the most positive cases found within the region of Africa, Latin America and the Caribbean, and of Asia. is known to have multiple strains which allow it to survive in the host cell epithelium chronically. Research has shown many factors which play a significant role in developing infection and thereafter its progression to gastric carcinoma. After colonizes the gastric mucosa, its effects can be potentiated by virulence factors, host factors, and environmental factors. contains virulence factors that aid in the adhesion, translocation, inflammation, and infectivity of the host gastric epithelium. It alters the functions of the host immune response and cytokines, utilizing these factors to invade and persist in the gastric epithelium for a long period of time. The human body will identify to be foreign and will exacerbate an inflammatory response in an effort to eradicate the bacterium. Consequently, this will cause to induce a serious infection which may progress to cancer. In this review, we will discuss the various factors involved in the infectious process of and how they help the infection progress to gastric carcinoma. This will allow us to better understand and modulate treatments to effectively eradicate this bacterium before it triggers the body into developing cancer.