Christeff N, Michon C, Goertz G, Hassid J, Matheron S, Girard P M, Coulaud J P, Nunez E A
U.224 INSERM, Hôpital Xavier Bichat, Paris, France.
Eur J Cancer Clin Oncol. 1988 Jul;24(7):1179-83. doi: 10.1016/0277-5379(88)90125-3.
The serum free fatty acid (FFA), cortisol and urinary creatinine, 17-hydzoxycorticosteroid and 17-oxosteroid concentrations of acquired immunedeficiency syndrome (AIDS-I: beginning and AIDS-II: end phase) and AIDS-related complex (ARC) patients were determined. Both groups were compared to a control group (healthy men). ARC and AIDS-I patients. The ratios of stearic (C18:0) to oleic (C18:1) acid were 75%, P less than 0.01 (ARC) and 45%, P less than 0.05 (AIDS-I) greater than normal, due to a decrease in the relative percentage of monounsaturated fatty acids by 25%, P less than 0.001 (ARC) and 20%, P less than 0.01 (AIDS-I). In contrast, the relative percentage of polyunsaturated fatty acids was 85% greater than normal (P less than 0.001) in ARC and 100% greater than normal (P less than 0.001) in AIDS-I patients. Total FFA levels did not differ from controls. Serum cortisol levels were 35% (P less than 0.01) above normal in ARC and 60% (P less than 0.001) above normal in AIDS-I patients. Urinary 17-hydroxycorticosteroids and 17-oxosteroids were very low (2-3-fold lower than normal values, P less than 0.001) in both groups of patients. Urinary creatinine did not differ from controls. In AIDS-II patients the total FFA concentration was below normal 35% (P less than 0.01) and the stearic/oleic acid ratio was 50% above normal (P less than 0.05). The relative percentages of monounsaturated and polyunsaturated fatty acids in this group were similar to those of controls. Serum cortisol concentrations were significantly higher, 50% (P less than 0.001), but the urinary 17-hydroxycorticosteroids and 17-oxosteroids were 2-fold lower (P less than 0.001) than those of controls. Urinary creatinine did not differ from controls. These significant differences from normal may be implicated in the pathophysiology of AIDS and could represent not only a good index of diagnosis and prognosis, but also indicate new therapeutic approach to the disease.
测定了获得性免疫缺陷综合征（AIDS - I：初期和AIDS - II：末期）及艾滋病相关综合征（ARC）患者的血清游离脂肪酸（FFA）、皮质醇以及尿肌酐、17 - 羟皮质类固醇和17 - 氧类固醇的浓度。将这两组患者与一个对照组（健康男性）进行比较。ARC和AIDS - I患者。硬脂酸（C18:0）与油酸（C18:1）的比例分别为75%（P < 0.01，ARC）和45%（P < 0.05，AIDS - I），高于正常水平，这是由于单不饱和脂肪酸的相对百分比分别降低了25%（P < 0.001，ARC）和20%（P < 0.01，AIDS - I）。相比之下，ARC患者中多不饱和脂肪酸的相对百分比比正常水平高85%（P < 0.001），AIDS - I患者中则比正常水平高100%（P < 0.001）。总FFA水平与对照组无差异。ARC患者的血清皮质醇水平比正常水平高35%（P < 0.01），AIDS - I患者比正常水平高60%（P < 0.001）。两组患者的尿17 - 羟皮质类固醇和17 - 氧类固醇都非常低（比正常值低2 - 3倍，P < 0.001）。尿肌酐与对照组无差异。在AIDS - II患者中，总FFA浓度比正常水平低35%（P < 0.01），硬脂酸/油酸比例比正常水平高50%（P < 0.05）。该组中单不饱和脂肪酸和多不饱和脂肪酸的相对百分比与对照组相似。血清皮质醇浓度显著更高，高50%（P < 0.001），但尿17 - 羟皮质类固醇和17 - 氧类固醇比对照组低2倍（P < 0.001）。尿肌酐与对照组无差异。这些与正常情况的显著差异可能与艾滋病的病理生理学有关，不仅可能是诊断和预后的良好指标，还可能为该疾病指明新的治疗方法。
