Craniofacial Anomalies Rehabilitation Hospital - HRAC at University of São Paulo, Bauru, SP, 17012-900, Brazil.
Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry, University of São Paulo, Avenida do Café, S/N, Ribeirão Preto, SP, 14040-904, Brazil.
Benef Microbes. 2021 Aug 30;12(4):1-13. doi: 10.3920/BM2020.0143. Epub 2021 Jun 25.
Probiotics have aroused great interest as an adjunctive treatment to periodontal therapy, due to the frequent colonisation by periodontopathogens after therapy. The aim of this systematic review was to analyse in the scientific literature, evidence of the microbiological effects of probiotics as an adjunct to periodontal therapy in the treatment of periodontal diseases (PD). Only randomised controlled trials (RCT), evaluating the microbiological effect of probiotics as an adjunct to periodontal therapy. The authors conducted a search in PubMed/MEDLINE, LILACS, ScienceDirect, Web of Science and Cochrane Library to identify articles published in English until February 2020. The quality of the studies was assessed using the JADAD scale and the risk of bias was assessed according to the Cochrane Collaboration assessment tool. Of the 265 articles potentially relevant to this review, 10 studies were included. The most frequently used probiotic bacteria were those of the genus spp. and the time of administration of the probiotics was between 14 days to 3 months. Most studies have shown that the adjuvant use of probiotics reduces the total mean counts of gram-negative anaerobic species ( and ) and gram-negative coccobacillus () of subgingival plaque samples. Probiotics adjuvant to periodontal therapy reduces periodontopathogenic species in a greater proportion, compared only to periodontal therapy. Especially the strain, without combination with other strains, offered a greater reduction in pathogenic bacteria associated with greater destruction of periodontal tissues and deep periodontal pockets. Researchers should perform high-quality RCT, evaluating single strains without combinations, in order to observe the microbiological benefits as adjunctive treatment of PD.
益生菌作为牙周治疗的辅助治疗方法引起了极大的兴趣，因为治疗后牙周病病原体经常定植。本系统评价的目的是分析科学文献中益生菌作为牙周治疗辅助治疗牙周病（PD）的微生物学效应的证据。仅纳入评价益生菌作为牙周治疗辅助治疗的微生物学效应的随机对照试验（RCT）。作者在 PubMed/MEDLINE、LILACS、ScienceDirect、Web of Science 和 Cochrane Library 中进行检索，以确定截至 2020 年 2 月发表的英文文章。使用 JADAD 量表评估研究质量，根据 Cochrane 协作评估工具评估偏倚风险。在 265 篇可能与本综述相关的文章中，有 10 篇被纳入。最常使用的益生菌细菌是属 种的细菌，益生菌的给药时间为 14 天至 3 个月。大多数研究表明，辅助使用益生菌可减少龈下菌斑样本中革兰氏阴性厌氧菌（和）和革兰氏阴性球杆菌（）的总平均计数。与仅牙周治疗相比，牙周治疗辅助使用益生菌可更大比例地减少牙周病病原体。特别是 株，不与其他菌株联合使用，可降低与牙周组织破坏和深牙周袋相关的致病菌的比例更大。研究人员应进行高质量的 RCT，评估单一菌株而不联合使用，以观察作为 PD 辅助治疗的微生物学益处。
