• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

对映体大麻素:精神活性的立体特异性。

Enantiomeric cannabinoids: stereospecificity of psychotropic activity.

作者信息

Mechoulam R, Feigenbaum J J, Lander N, Segal M, Järbe T U, Hiltunen A J, Consroe P

机构信息

Brettler Medical Research Center, Faculty of Medicine, Hebrew University, Jerusalem, Israel.

出版信息

Experientia. 1988 Sep 15;44(9):762-4. doi: 10.1007/BF01959156.

DOI:10.1007/BF01959156
PMID:3416993
Abstract

The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).

摘要

(-)-(3R,4R)-7-羟基-δ-6-四氢大麻酚(化合物II)的1,1-二甲基庚基同系物在小鼠、大鼠和鸽子中具有高度精神活性。已发现(+)-(3S,4S)对映体(III)在剂量高达化合物(II)半数有效剂量(ED50)的数千倍时,精神活性无作用。

相似文献

1
Enantiomeric cannabinoids: stereospecificity of psychotropic activity.对映体大麻素:精神活性的立体特异性。
Experientia. 1988 Sep 15;44(9):762-4. doi: 10.1007/BF01959156.
2
Cannabimimetic activity of novel enantiomeric, benzofuran cannabinoids.新型对映体苯并呋喃大麻素的拟大麻活性
J Med Chem. 1990 Mar;33(3):1037-43. doi: 10.1021/jm00165a024.
3
Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-delta 8-tetrahydrocannabinol in rats and pigeons.
J Pharmacol Exp Ther. 1989 Sep;250(3):1000-5.
4
Discriminative stimulus- and open-field effects of the enantiomers of 11-hydroxy-delta-8-tetrahydrocannabinol in pigeons and gerbils.
Pharmacol Biochem Behav. 1994 Jan;47(1):113-9. doi: 10.1016/0091-3057(94)90119-8.
5
Effect of synthetic enantiomeric cannabinoids on platelet aggregation.
Can J Physiol Pharmacol. 1992 Oct;70(10):1305-8. doi: 10.1139/y92-182.
6
Stereochemical requirements for cannabimimetic activity.大麻模拟活性的立体化学要求。
NIDA Res Monogr. 1987;79:15-30.
7
Inhibition of cisplatin-induced emesis in the pigeon by a non-psychotropic synthetic cannabinoid.一种非精神活性合成大麻素对顺铂诱导的鸽子呕吐的抑制作用。
Eur J Pharmacol. 1989 Oct 4;169(1):159-65. doi: 10.1016/0014-2999(89)90828-5.
8
Prostaglandins and cannabis XV. Comparison of enantiomeric cannabinoids in stimulating prostaglandin synthesis in fibroblasts.前列腺素与大麻素十五。成纤维细胞中对映体大麻素刺激前列腺素合成的比较。
Life Sci. 1986 Nov 10;39(19):1813-23. doi: 10.1016/0024-3205(86)90101-3.
9
Pharmacology and stereoselectivity of structurally novel cannabinoids in mice.新型结构大麻素在小鼠体内的药理学及立体选择性
J Pharmacol Exp Ther. 1988 Dec;247(3):1046-51.
10
Separation of the discriminative stimulus effects of stereoisomers of delta 2- and delta 3-tetrahydrocannabinols in pigeons.
Eur J Pharmacol. 1988 Nov 8;156(3):361-6. doi: 10.1016/0014-2999(88)90281-6.

引用本文的文献

1
Crystal structures of agonist-bound human cannabinoid receptor CB.激动剂结合型人大麻素受体CB的晶体结构
Nature. 2025 Aug 27. doi: 10.1038/s41586-025-09454-5.
2
Advances in cannabinoid receptors pharmacology: from receptor structural insights to ligand discovery.大麻素受体药理学进展:从受体结构洞察到配体发现
Acta Pharmacol Sin. 2025 Feb 5. doi: 10.1038/s41401-024-01472-9.
3
Effects of psychedelics on neurogenesis and broader neuroplasticity: a systematic review.迷幻剂对神经发生及更广泛神经可塑性的影响:一项系统综述

本文引用的文献

1
A repeated test procedure to assess onset and duration of the cue properties of (-) delta 9-THC, (-) delta 8-THC-DMH and (+) delta 8-THC.
Psychopharmacology (Berl). 1981;75(2):152-7. doi: 10.1007/BF00432178.
2
A stereospecific synthesis of (-)-delta 1- and (-)-delta 1(6)-tetrahydrocannabinols.(-)-δ¹-和(-)-δ¹(6)-四氢大麻酚的立体定向合成。
J Am Chem Soc. 1967 Aug 16;89(17):4552-4. doi: 10.1021/ja00993a072.
3
The ring test: a quantitative method for assessing the 'cataleptic' effect of cannabis in mice.环形试验:一种评估大麻对小鼠“僵住症”效应的定量方法。
Mol Med. 2024 Dec 19;30(1):244. doi: 10.1186/s10020-024-01013-4.
4
An emerging trend in Novel Psychoactive Substances (NPSs): designer THC.新型精神活性物质(NPSs)的一个新趋势:合成大麻素。
J Cannabis Res. 2024 May 3;6(1):21. doi: 10.1186/s42238-024-00226-y.
5
Unexpected improvement of hyperhidrosis with cannabidiol.意想不到的大麻二酚对多汗症的改善作用。
Einstein (Sao Paulo). 2022 Feb 14;20:eRC5795. doi: 10.31744/einstein_journal/2022RC5795. eCollection 2022.
6
Major Phytocannabinoids and Their Related Compounds: Should We Only Search for Drugs That Act on Cannabinoid Receptors?主要植物大麻素及其相关化合物:我们是否应该只寻找作用于大麻素受体的药物?
Pharmaceutics. 2021 Nov 1;13(11):1823. doi: 10.3390/pharmaceutics13111823.
7
The neuropharmacology of cannabinoid receptor ligands in central signaling pathways.大麻素受体配体在中枢信号通路中的神经药理学。
Eur J Neurosci. 2022 Feb;55(4):909-921. doi: 10.1111/ejn.14982. Epub 2020 Dec 5.
8
Cannabinoid ligands, receptors and enzymes: Pharmacological tools and therapeutic potential.大麻素配体、受体与酶:药理学工具及治疗潜力
Brain Neurosci Adv. 2018 Jun 19;2:2398212818783908. doi: 10.1177/2398212818783908. eCollection 2018 Jan-Dec.
9
Effects of cannabinoids on the development of chick embryos in ovo.大麻素对鸡胚在卵内发育的影响。
Sci Rep. 2019 Sep 17;9(1):13486. doi: 10.1038/s41598-019-50004-7.
10
Selective modulation of the cannabinoid type 1 (CB) receptor as an emerging platform for the treatment of neuropathic pain.对1型大麻素(CB)受体的选择性调节作为治疗神经性疼痛的新兴平台。
Medchemcomm. 2019 Mar 18;10(5):647-659. doi: 10.1039/c8md00595h. eCollection 2019 May 1.
Br J Pharmacol. 1972 Dec;46(4):753-63. doi: 10.1111/j.1476-5381.1972.tb06900.x.
4
Cannabinoid pharmacology.大麻素药理学
Pharmacol Rev. 1986 Jun;38(2):151-78.
5
Cannabimimetic activity (delta 1-THC cue) of cannabidiol monomethyl ether and two stereoisomeric hexahydrocannabinols in rats and pigeons.大麻二酚单甲醚和两种立体异构的六氢大麻酚在大鼠和鸽子体内的拟大麻活性(δ1-四氢大麻酚线索)
Pharmacol Biochem Behav. 1986 Aug;25(2):393-9. doi: 10.1016/0091-3057(86)90015-8.
6
Structure-activity relationships in cannabinoids.大麻素的构效关系
Pharmacol Rev. 1986 Jun;38(2):75-149.
7
Interactions between delta 9-tetrahydrocannabinol and cannabidiol as evaluated by drug discrimination procedures in rats and pigeons.通过大鼠和鸽子的药物辨别程序评估Δ9-四氢大麻酚与大麻二酚之间的相互作用。
Neuropharmacology. 1986 Feb;25(2):133-42. doi: 10.1016/0028-3908(86)90034-1.
8
Cellular effects of cannabinoids.大麻素的细胞效应。
Pharmacol Rev. 1986 Mar;38(1):45-74.
9
Cannabidiol--antiepileptic drug comparisons and interactions in experimentally induced seizures in rats.大麻二酚——大鼠实验性诱发癫痫中抗癫痫药物的比较与相互作用
J Pharmacol Exp Ther. 1977 Apr;201(1):26-32.