Mechoulam R, Feigenbaum J J, Lander N, Segal M, Järbe T U, Hiltunen A J, Consroe P
Brettler Medical Research Center, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Experientia. 1988 Sep 15;44(9):762-4. doi: 10.1007/BF01959156.
The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).
(-)-(3R,4R)-7-羟基-δ-6-四氢大麻酚(化合物II)的1,1-二甲基庚基同系物在小鼠、大鼠和鸽子中具有高度精神活性。已发现(+)-(3S,4S)对映体(III)在剂量高达化合物(II)半数有效剂量(ED50)的数千倍时,精神活性无作用。