Surgery, Royal Berkshire NHS Foundation Trust, Reading, UK
Obstetrics, Liverpool Women's Hospital, Liverpool, UK.
BMJ Case Rep. 2021 Jun 25;14(6):e243872. doi: 10.1136/bcr-2021-243872.
Although ovarian vein thrombosis (OVT) is classically considered a puerperal pathology, it can also occur in nonpuerperal settings such as endometritis, pelvic inflammatory disease, Crohn's disease, pelvic or gynaecological surgeries and thrombophilia. Hypercoagulation conditions such as antiphospholipid syndrome, systemic lupus erythematosus, factor V Leiden and protein C and S deficiency are all recognised risk factors. It is also a known complication during pregnancy often presenting with fever and lower abdominal pain within weeks after delivery. Its incidence is exceedingly rare, occurring in 0.05% of all pregnancies that result in live births and peaking around 2-6 days after delivery. Its preferential involvement of the right ovarian vein may be explained by the compression of the inferior vena cava and the right ovarian vein due to dextrorotation of the uterus during pregnancy. Furthermore, antegrade flow of blood and multiple incompetent valves in the right ovarian vein favours bacterial infection. Complications may include sepsis and thrombus extension to the inferior vena cava or left renal vein and rarely, pulmonary embolism. The authors present the case of a 27-year-old woman with lower abdominal pain 5 weeks after an elective caesarean section. Although the diagnosis of postpartum endometritis was initially considered, a CT suggested a right OVT. She commenced treatment with low-molecular weight heparin. A high index of clinical suspicion is required in order to establish the diagnosis of this rare cause of abdominal pain, which can mimic an acute abdomen.
虽然卵巢静脉血栓形成(OVT)通常被认为是产褥期的一种病理现象,但它也可能发生在非产褥期的情况下,如子宫内膜炎、盆腔炎、克罗恩病、盆腔或妇科手术以及血栓形成倾向。高凝状态如抗磷脂综合征、系统性红斑狼疮、因子 V Leiden 和蛋白 C 和 S 缺乏症都是公认的危险因素。它也是妊娠期间的一种已知并发症,通常在分娩后数周内出现发热和下腹痛。其发病率极低,在所有导致活产的妊娠中发生率为 0.05%,在分娩后 2-6 天达到高峰。其右侧卵巢静脉的优先受累可能是由于妊娠期间子宫右旋导致下腔静脉和右侧卵巢静脉受压所致。此外,血流的逆行和右侧卵巢静脉中的多个功能不全的瓣膜有利于细菌感染。并发症可能包括败血症和血栓延伸至下腔静脉或左肾静脉,罕见情况下还会发生肺栓塞。作者报告了一例 27 岁女性在选择性剖宫产术后 5 周出现下腹痛的病例。尽管最初考虑诊断为产后子宫内膜炎,但 CT 提示右侧 OVT。她开始接受低分子量肝素治疗。为了建立这种罕见的腹痛原因的诊断,需要高度的临床怀疑,因为它可能模仿急性腹痛。