University of Tennessee, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, Knoxville, TN, USA; Erciyes University, College of Veterinary Medicine, Department of Virology, Kayseri, Turkey.
University of Tennessee, Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, Knoxville, TN, USA; Dr. Yashwant Singh Parmar University of Horticulture and Forestry, Department of Silviculture and Agroforestry, College of Forestry, Solan, Himachal Pradesh, India.
J Infect Public Health. 2021 Aug;14(8):1051-1064. doi: 10.1016/j.jiph.2021.06.007. Epub 2021 Jun 17.
Zoonotic coronaviruses have caused several endemic and pandemic situations around the world. SARS caused the first epidemic alert at the beginning of this century, followed by MERS. COVID-19 appeared to be highly contagious, with human-to-human transmission by aerosol droplets, and reached nearly all countries around the world. A plethora of studies were performed, with reports being published within a short period of time by scientists and medical physicians. It has been difficult to find the relevant data to create an overview of the situation according to studies from accumulated findings and reports. In the present study we aimed to perform a comprehensive study in the context of the case fatality ratios (CFRs) of three major human Coronavirus outbreaks which occurred during the first twenty years of 21st century.
In this study, we performed meta-analyses on SARS, MERS and COVID-19 outbreak events from publicly available records. Study analyses were performed with the help of highly reputable scientific databases such as PubMed, WOS and Scopus to evaluate and present current knowledge on zoonotic coronavirus outbreaks, starting from 2000 to the end of 2020.
A total of 250,194 research studies and records were identified with specific keywords and synonyms for the three viruses in order to cover all publications. In the end, 41 records were selected and included after applying several exclusion and inclusion criteria on identified datasets. SARS was found to have a nearly 11% case fatality ratio (CFR), which means the estimated number of deaths as a proportion of confirmed positive cases; Taiwan was the country most affected by the SARS outbreak based on the CFR analysis. MERS had CFRs of 35.8 and 26 in Saudi Arabia during the 2012 and 2015 outbreaks, respectively. COVID-19 resulted in a 2.2 CFR globally, and the USA reported the highest mortality ratio in the world in the end of first year of COVID-19 pandemic.
Some members of the Coronaviridae family can cause highly contagious and devastating infections among humans. Within the last two decades, the whole world has witnessed several deadly emerging infectious diseases, which are most commonly zoonotic in nature. We conclude that pre-existing immunity during the early stages of a pandemic might be important, but case control and management strategies should be improved to decrease CFRs. Finally, we have addressed several concerns in relation to outbreak events in this study.
人畜共患冠状病毒已在全球范围内引发了多次地方性和大流行疫情。SARS 在本世纪初引发了首次疫情警报，随后是 MERS。COVID-19 似乎具有高度传染性，可通过气溶胶飞沫在人与人之间传播，并已传播到全球几乎所有国家。大量研究得以开展，科学家和临床医生在短时间内发表了报告。根据已积累的研究结果和报告，很难找到相关数据来全面了解情况。在本研究中，我们旨在针对 21 世纪头 20 年期间发生的三种主要人类冠状病毒爆发的病死率（CFR）进行综合研究。
本研究对公开记录中的 SARS、MERS 和 COVID-19 爆发事件进行了荟萃分析。借助 PubMed、WOS 和 Scopus 等知名科学数据库对研究进行了分析，以评估和展示 2000 年至 2020 年底期间人畜共患冠状病毒爆发的最新知识。
通过使用 SARS、MERS 和 COVID-19 三种病毒的特定关键词和同义词，共确定了 250194 项研究和记录，以涵盖所有出版物。最终，在对确定的数据集中应用了一些排除和纳入标准后，选择并纳入了 41 条记录。SARS 的病死率（CFR）接近 11%，这意味着死亡人数占确诊阳性病例的比例；根据 CFR 分析，台湾是 SARS 爆发最严重的国家。2012 年和 2015 年 MERS 爆发期间，沙特阿拉伯的 CFR 分别为 35.8 和 26。COVID-19 在全球的 CFR 为 2.2，2020 年初，美国报告的 COVID-19 死亡率居全球首位。
冠状病毒科的一些成员可导致人类高度传染性和破坏性感染。在过去的二十年中，全世界见证了几次致命的新发传染病，这些传染病通常是人畜共患的。我们得出结论，大流行早期的预先存在的免疫可能很重要，但病例对照和管理策略应加以改进，以降低 CFR。最后，我们在本研究中提出了与爆发事件相关的几个关注点。
Zotero 插件
