冠心病与 ADAMTS7 相关是由于其蛋白酶活性。
Coronary Disease Association With ADAMTS7 Is Due to Protease Activity.
机构信息
Cardiovascular Disease Initiative (T.M., B.T.M., B.B., N.R.P., A.A., D.L., Q.M.Z., S.K., P.T.E.), Broad Institute of MIT and Harvard, Cambridge, MA.
Now with Verve Therapeutics, Cambridge, MA, USA (T.M., S.K.).
出版信息
Circ Res. 2021 Aug 6;129(4):458-470. doi: 10.1161/CIRCRESAHA.121.319163. Epub 2021 Jun 28.
Abstract
[Figure: see text].
摘要
[图：见正文]。
相似文献
1
Coronary Disease Association With ADAMTS7 Is Due to Protease Activity.冠心病与 ADAMTS7 相关是由于其蛋白酶活性。
Circ Res. 2021 Aug 6;129(4):458-470. doi: 10.1161/CIRCRESAHA.121.319163. Epub 2021 Jun 28.
2
ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant.ADAMTS7 的裂解和血管平滑肌细胞迁移受与冠状动脉疾病相关的变异影响。
Am J Hum Genet. 2013 Mar 7;92(3):366-74. doi: 10.1016/j.ajhg.2013.01.012. Epub 2013 Feb 14.
3
ADAMTS7: a Novel Therapeutic Target in Atherosclerosis.ADAMTS7：动脉粥样硬化的新治疗靶点。
Curr Atheroscler Rep. 2023 Aug;25(8):447-455. doi: 10.1007/s11883-023-01115-0. Epub 2023 Jun 24.
4
ADAMTS7: Recombinant Protein Expression and Purification.ADAMTS7：重组蛋白的表达与纯化
Methods Mol Biol. 2020;2043:63-73. doi: 10.1007/978-1-4939-9698-8_6.
5
ADAMTS7: a promising new therapeutic target in coronary heart disease.ADAMTS7：冠心病治疗的新靶点。
Expert Opin Ther Targets. 2013 Aug;17(8):863-7. doi: 10.1517/14728222.2013.816287. Epub 2013 Jul 6.
6
Genetic Variation at the Locus is Associated With Reduced Severity of Coronary Artery Disease.该位点的遗传变异与冠状动脉疾病严重程度降低有关。
J Am Heart Assoc. 2017 Oct 31;6(11):e006928. doi: 10.1161/JAHA.117.006928.
7
Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease.ADAMTS7基因多态性与冠心病心血管生存的关联
Physiol Genomics. 2016 Nov 1;48(11):810-815. doi: 10.1152/physiolgenomics.00059.2016. Epub 2016 Sep 9.
8
Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice.敲除人类新型冠心病相关基因座Adamts7可减轻小鼠动脉粥样硬化。
Circulation. 2015 Mar 31;131(13):1202-1213. doi: 10.1161/CIRCULATIONAHA.114.012669. Epub 2015 Feb 20.
9
BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.BAY-9835：首个口服生物可利用的 ADAMTS7 抑制剂的发现。
J Med Chem. 2024 Feb 22;67(4):2907-2940. doi: 10.1021/acs.jmedchem.3c02036. Epub 2024 Feb 13.
10
ADAMTS7 and ZC3HC1 Share Genetic Predisposition to Coronary Artery Disease and Large Artery Ischemic Stroke.ADAMTS7和ZC3HC1在冠状动脉疾病和大动脉缺血性卒中方面具有共同的遗传易感性。
Crit Rev Eukaryot Gene Expr. 2019;29(4):351-361. doi: 10.1615/CritRevEukaryotGeneExpr.2019028209.
引用本文的文献
1
Genetic predisposition to immune dysregulation and extracellular matrix remodeling in cardiac arrhythmia reveals potential mediation by + macrophages.心律失常中免疫失调和细胞外基质重塑的遗传易感性揭示了+巨噬细胞的潜在介导作用。
Front Cell Dev Biol. 2025 Aug 18;13:1611663. doi: 10.3389/fcell.2025.1611663. eCollection 2025.
2
The Pathophysiological Role of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm.血管平滑肌细胞在腹主动脉瘤中的病理生理作用
Cells. 2025 Jul 2;14(13):1009. doi: 10.3390/cells14131009.
3
Vaccination as a Promising Approach in Cardiovascular Risk Mitigation: Are We Ready to Embrace a Vaccine Strategy?接种疫苗作为减轻心血管风险的一种有前景的方法：我们准备好接受疫苗策略了吗？
Biomolecules. 2024 Dec 20;14(12):1637. doi: 10.3390/biom14121637.
4
Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables.使用一组相关的工具变量预测具有基因调控多效性的 GWAS 位点的因果基因。
PLoS Genet. 2024 Nov 11;20(11):e1011473. doi: 10.1371/journal.pgen.1011473. eCollection 2024 Nov.
5
Design, synthesis and biological evaluation of arylsulfonamides as ADAMTS7 inhibitors.作为ADAMTS7抑制剂的芳基磺酰胺的设计、合成及生物学评价
RSC Med Chem. 2024 Jun 19;15(8):2806-2825. doi: 10.1039/d4md00149d. eCollection 2024 Aug 14.
6
The Role of Genetics in Advancing Cardiometabolic Drug Development.遗传学在推进心脏代谢药物研发中的作用。
Curr Atheroscler Rep. 2024 May;26(5):153-162. doi: 10.1007/s11883-024-01195-6. Epub 2024 Mar 7.
7
The Association of Gene Polymorphisms with the Risk of Coronary Artery Disease Occurrence and Cardiovascular Survival in the Polish Population: A Case-Control and a Prospective Cohort Study.基因多态性与波兰人群冠心病发病风险及心血管生存的相关性：病例对照和前瞻性队列研究。
Int J Mol Sci. 2024 Feb 14;25(4):2274. doi: 10.3390/ijms25042274.
8
BAY-9835: Discovery of the First Orally Bioavailable ADAMTS7 Inhibitor.BAY-9835：首个口服生物可利用的 ADAMTS7 抑制剂的发现。
J Med Chem. 2024 Feb 22;67(4):2907-2940. doi: 10.1021/acs.jmedchem.3c02036. Epub 2024 Feb 13.
9
10
ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1.ADAMTS-7 通过降解 TIMP-1 调节动脉粥样硬化斑块的形成。
Circ Res. 2023 Sep 29;133(8):674-686. doi: 10.1161/CIRCRESAHA.123.322737. Epub 2023 Sep 7.
本文引用的文献
1
Association between ADAMTS7 polymorphism and carotid artery plaque vulnerability.ADAMTS7基因多态性与颈动脉斑块易损性之间的关联。
Medicine (Baltimore). 2019 Oct;98(43):e17438. doi: 10.1097/MD.0000000000017438.
2
ADAMTS7: Recombinant Protein Expression and Purification.ADAMTS7：重组蛋白的表达与纯化
Methods Mol Biol. 2020;2043:63-73. doi: 10.1007/978-1-4939-9698-8_6.
3
Proteomic discovery of substrates of the cardiovascular protease ADAMTS7.心血管蛋白酶 ADAMTS7 的底物的蛋白质组学发现。
J Biol Chem. 2019 May 17;294(20):8037-8045. doi: 10.1074/jbc.RA119.007492. Epub 2019 Mar 29.
4
ADAMTS proteins in human disorders.人类疾病中的 ADAMTS 蛋白。
Matrix Biol. 2018 Oct;71-72:225-239. doi: 10.1016/j.matbio.2018.06.002. Epub 2018 Jun 6.
5
The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.金属蛋白酶-蛋白聚糖 ADAMTS7 和 ADAMTS12 为异位骨化提供了一种先天的、肌腱特异性的保护机制。
JCI Insight. 2018 Apr 5;3(7). doi: 10.1172/jci.insight.92941.
6
A decade of genome-wide association studies for coronary artery disease: the challenges ahead.一项针对冠心病的全基因组关联研究十年：未来的挑战。
Cardiovasc Res. 2018 Jul 15;114(9):1241-1257. doi: 10.1093/cvr/cvy084.
7
Monoclonal antibodies against metzincin targets.针对金属蛋白酶靶点的单克隆抗体。
Br J Pharmacol. 2019 Jan;176(1):52-66. doi: 10.1111/bph.14186. Epub 2018 Apr 2.
8
Genetic Variation at the Locus is Associated With Reduced Severity of Coronary Artery Disease.该位点的遗传变异与冠状动脉疾病严重程度降低有关。
J Am Heart Assoc. 2017 Oct 31;6(11):e006928. doi: 10.1161/JAHA.117.006928.
9
ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis.ADAMTS-7 与人类动脉粥样硬化中的高危斑块表型有关。
Sci Rep. 2017 Jun 16;7(1):3753. doi: 10.1038/s41598-017-03573-4.
10
Genetics of coronary artery disease: discovery, biology and clinical translation.冠状动脉疾病的遗传学：发现、生物学及临床转化
Nat Rev Genet. 2017 Jun;18(6):331-344. doi: 10.1038/nrg.2016.160. Epub 2017 Mar 13.
Zotero 插件