Yao Runhong, Nishii Kazuhiro, Aizu Naoki, Kito Takumi, Sakai Kazuyoshi, Yamada Kouji
Graduate School of Health Sciences, Fujita Health University, Toyoake, Japan.
Dement Geriatr Cogn Dis Extra. 2021 May 19;11(2):114-121. doi: 10.1159/000515957. eCollection 2021 May-Aug.
Patients with dementia show reduced adaptive, behavioral, and physiological responses to environmental threats. Physical exercise is expected to delay brain aging, maintain cognitive function and, consequently, help dementia patients face threats and protect themselves skillfully.
To confirm this, we aimed to investigate the effects of the shaking exercise on the avoidance function in the senescence-accelerated mouse-prone strain-10 (SAMP-10) model at the behavioral and tissue levels. SAMP-10 mice were randomized into 2 groups: a control group and a shaking group. The avoidance response (latency) of the mice was evaluated using a passive avoidance task. The degree of amygdala and hippocampal aging was evaluated based on the brain morphology. Subsequently, the association between avoidance response and the degree of amygdala-hippocampal aging was evaluated.
Regarding the passive avoidance task, the shaking group showed a longer latency period than the control group ( < 0.05), even and low intensity staining of ubiquitinated protein, and had a higher number of and larger neurons than those of the control group. The difference between the groups was more significant in the BA region of the amygdala and the CA1 region of the hippocampus (staining degree: < 0.05, neuron size: < 0.01, neuron counts: < 0.01) than in other regions.
The shaking exercise prevents nonfunctional protein (NFP) accumulation, neuron atrophy, and neuron loss; delays the aging of the amygdala and hippocampus; and maintains the function of the amygdala-hippocampal circuit. It thus enhances emotional processing and cognition functions, the memory of threats, the skillful confrontation of threats, and proper self-protection from danger.
痴呆症患者对环境威胁的适应性、行为和生理反应会降低。体育锻炼有望延缓大脑衰老，维持认知功能，从而帮助痴呆症患者应对威胁并巧妙地保护自己。
为证实这一点，我们旨在从行为和组织层面研究抖动运动对衰老加速小鼠易患10型（SAMP - 10）模型回避功能的影响。将SAMP - 10小鼠随机分为两组：对照组和抖动组。使用被动回避任务评估小鼠的回避反应（潜伏期）。根据脑形态学评估杏仁核和海马体的衰老程度。随后，评估回避反应与杏仁核 - 海马体衰老程度之间的关联。
在被动回避任务方面，抖动组的潜伏期比对照组更长（<0.05），泛素化蛋白染色均匀且强度低，并且与对照组相比，神经元数量更多、体积更大。两组之间的差异在杏仁核的基底外侧核区域和海马体的CA1区域更为显著（染色程度：<0.05，神经元大小：<0.01，神经元数量：<0.01），比其他区域更明显。
抖动运动可防止无功能蛋白（NFP）积累、神经元萎缩和神经元丢失；延缓杏仁核和海马体的衰老；并维持杏仁核 - 海马体回路的功能。因此，它增强了情绪处理和认知功能、对威胁的记忆、对威胁的巧妙应对以及对危险的适当自我保护。
