多成分训练后阿尔茨海默病所致遗忘型轻度认知障碍患者的认知和脑结构变化
Cognitive and structural cerebral changes in amnestic mild cognitive impairment due to Alzheimer's disease after multicomponent training.
作者信息
Teixeira Camila Vieira Ligo, Ribeiro de Rezende Thiago Junqueira, Weiler Marina, Magalhães Thamires Naela Cardoso, Carletti-Cassani Ana Flávia Mac Knight, Silva Thiago Quinaglia Araújo Costa, Joaquim Helena Passarelli Giroud, Talib Leda Leme, Forlenza Orestes Vicente, Franco Mariana Pires, Nechio Pedro Eduardo, Fernandes Paula Teixeira, Cendes Fernando, Balthazar Marcio Luis
机构信息
Neuroimage Laboratory (LNI), Department of Neurology, Medical Sciences Faculty, UNICAMP, Campinas, São Paulo, Brazil.
Brazilian Institute of Neuroscience and Neurotechnology, Campinas, São Paulo, Brazil.
出版信息
Alzheimers Dement (N Y). 2018 Aug 30;4:473-480. doi: 10.1016/j.trci.2018.02.003. eCollection 2018.
INTRODUCTION
Information about how physical exercise affects patients with amnestic mild cognitive impairment (aMCI) due to Alzheimer's disease (AD) is still missing. This study evaluated the impact of multicomponent exercise training on cognition and brain structure in aMCI subjects with cerebral spinal fluid positive AD biomarkers.
METHODS
Forty aMCI subjects were divided in training (multicomponent exercise thrice a week for 6 months) and nontraining groups. Assessments included cardiorespiratory fitness, neurocognitive tests, and a structural magnetic resonance imaging using 3.0 T scanner. FreeSurfer software analyzed hippocampal volume and cortical thickness.
RESULTS
The training group showed increased volume in both hippocampi and better performance in episodic memory test after 6 months. In contrast, the nontraining group declined in functional activities, recognition, and cardiorespiratory fitness for the same period.
DISCUSSION
Multicomponent exercise seems to improve hippocampal volume and episodic memory, and maintains VO in aMCI due to AD.
引言
关于体育锻炼如何影响阿尔茨海默病（AD）所致遗忘型轻度认知障碍（aMCI）患者的信息仍然缺失。本研究评估了多组分运动训练对脑脊液AD生物标志物呈阳性的aMCI受试者认知和脑结构的影响。
方法
40名aMCI受试者被分为训练组（每周进行三次多组分运动，持续6个月）和非训练组。评估包括心肺适能、神经认知测试以及使用3.0T扫描仪进行的结构磁共振成像。FreeSurfer软件分析海马体积和皮质厚度。
结果
6个月后，训练组双侧海马体积增加，情景记忆测试表现更好。相比之下，同期非训练组的功能活动、识别能力和心肺适能下降。
讨论
多组分运动似乎能改善海马体积和情景记忆，并维持由AD所致aMCI患者的VO。
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