Plays a Role in Early Biofilm Formation, Interaction With and Virulence in .

The yeast exhibits multiple morphologies dependent on environmental cues. biofilms are frequently polymicrobial, enabling interspecies interaction through proximity and contact. The interaction between and the bacterium, , is antagonistic repressing the yeast-to-hyphal switch in . Previous transcriptional analysis of in polymicrobial biofilms with revealed upregulation of genes involved in regulation of morphology and biofilm formation, including , a component of the Set3/Hos2 histone deacetylase complex (Set3C). This prompted the question regarding the involvement of in the interaction between and , both and We found that may influence early biofilm formation by and the interaction between and . In addition, although deletion of did not alter the morphology of in the presence of , it did cause a reduction in virulence in a infection model, even in the presence of