Fourie Ruan, Pohl Carolina H
Department of Microbial, Biochemical and Food Biotechnology, University of the Free State, Bloemfontein 9301, South Africa.
J Fungi (Basel). 2019 Apr 19;5(2):34. doi: 10.3390/jof5020034.
There are many examples of the interaction between prokaryotes and eukaryotes. One such example is the polymicrobial colonization/infection by the various opportunistic pathogenic yeasts belonging to the genus and the ubiquitous bacterium, . Although this interaction has simplistically been characterized as antagonistic to the yeast, this review highlights the complexity of the interaction with various factors influencing both microbes. The first section deals with the interactions , looking specifically at the role of cell wall components, quorum sensing molecules, phenazines, fatty acid metabolites and competition for iron in the interaction. The second part of this review places all these interactions in the context of various infection or colonization sites, i.e., lungs, wounds, and the gastrointestinal tract. Here we see that the role of the host, as well as the methodology used to establish co-infection, are important factors, influencing the outcome of the disease. Suggested future perspectives for the study of this interaction include determining the influence of newly identified participants of the QS network of , oxylipin production by both species, as well as the genetic and phenotypic plasticity of these microbes, on the interaction and outcome of co-infection.
原核生物与真核生物之间相互作用的例子有很多。其中一个例子是由属于该属的各种机会致病性酵母和无处不在的细菌进行的多微生物定植/感染。尽管这种相互作用被简单地描述为对酵母具有拮抗作用，但本综述强调了这种相互作用的复杂性，其中各种因素会影响这两种微生物。第一部分论述了这些相互作用，特别着眼于细胞壁成分、群体感应分子、吩嗪、脂肪酸代谢产物以及相互作用中铁竞争的作用。本综述的第二部分将所有这些相互作用置于各种感染或定植部位的背景下，即肺部、伤口和胃肠道。在这里我们看到，宿主的作用以及用于建立共同感染的方法是影响疾病结果的重要因素。关于这种相互作用研究的未来建议方向包括确定新发现的该群体感应网络参与者、两种物种的氧脂生成以及这些微生物的遗传和表型可塑性对共同感染的相互作用和结果的影响。
