Saif-Ali Riyadh, Al-Hamodi Zaid, Salem Sameer D, Al-Habori Molham, Al-Dubai Sami A, Ismail Ikram S
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Sana'a University, Sana'a, Yemen.
Joint Program of Preventive Medicine, Post Graduate Studies, Medina, Saudi Arabia.
Indian J Endocrinol Metab. 2024 Jan-Feb;28(1):55-59. doi: 10.4103/ijem.ijem_209_23. Epub 2024 Feb 26.
Type 2 diabetes (T2D) candidate genes, protein tyrosine phosphatase receptor type D (PTPRD), and serine racemase (SRR) were suggested by a genome-wide association study (GWAS) in the Chinese population. Association studies have been replicated among East Asian populations. The association of PTPRD and SRR genetic variants with T2D in Southeast Asian populations still needs to be studied. This study aimed to investigate the association of PTPRD and SSR genetic variants with T2D in Malaysian Indian subjects.
The single nucleotide polymorphisms (SNPs) of PTPRD (rs649891 and rs17584499) and SRR (rs4523957, rs391300, and rs8081273) were genotyped in 397 T2D and 285 normal Malaysian Indian subjects.
The homozygous dominant genotype of rs17584499 is frequent in diabetic patients (56.5%) compared to normal subjects (47.3%). In contrast, the homozygous recessive genotype of rs8081273 is more frequent among normal subjects (12.5%) than diabetic patients (5.6%). The dominant genetic model showed that PTPRD rs17584499 (CC) is a risk factor for T2D (OR = 1.42, = 0.029), whereas the recessive genetic model showed that SRS SNP rs8081273 was protective for T2D (OR = 0.42, = 0.003).
This study confirmed the association of PTPRD rs17584499 genetic variations with T2D in Malaysian Indians. While the SRR rs8081273 (TT) genotype showed protection against T2D, more investigation in different populations is required to confirm this protection.
全基因组关联研究（GWAS）在中国人群中发现了2型糖尿病（T2D）候选基因，蛋白酪氨酸磷酸酶受体D型（PTPRD）和丝氨酸消旋酶（SRR）。关联研究已在东亚人群中得到重复验证。PTPRD和SRR基因变异与东南亚人群T2D的关联仍有待研究。本研究旨在调查马来西亚印度裔受试者中PTPRD和SSR基因变异与T2D的关联。
对397例马来西亚印度裔T2D患者和285例正常受试者进行PTPRD（rs649891和rs17584499）和SRR（rs4523957、rs391300和rs8081273）单核苷酸多态性（SNP）基因分型。
与正常受试者（47.3%）相比，rs17584499的纯合显性基因型在糖尿病患者中更为常见（56.5%）。相比之下，rs8081273的纯合隐性基因型在正常受试者中（12.5%）比糖尿病患者（5.6%）更为常见。显性遗传模型显示，PTPRD rs17584499（CC）是T2D的危险因素（OR = 1.42，P = 0.029），而隐性遗传模型显示，SRS SNP rs8081273对T2D具有保护作用（OR = 0.42，P = 0.003）。
本研究证实了PTPRD rs17584499基因变异与马来西亚印度裔人群T2D的关联。虽然SRR rs8081273（TT）基因型显示出对T2D的保护作用，但需要在不同人群中进行更多研究以证实这种保护作用。
