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生物安全与生物样本库:当前的认识与知识空白

Biosafety and biobanking: Current understanding and knowledge gaps.

作者信息

Roux Julie, Zeghidi Maissa, Villar Stephanie, Kozlakidis Zisis

机构信息

World Health Organization, International Agency for Research on Cancer, Lyon, France.

Ecole Supérieure de Biologie-Biochimie-Biotechnologies, Université Catholique de Lyon, Lyon, France.

出版信息

Biosaf Health. 2021 Oct;3(5):244-248. doi: 10.1016/j.bsheal.2021.06.003. Epub 2021 Jun 19.

Abstract

Infectious disease outbreaks, such as 'Coronavirus disease 2019' (COVID-19), can constitute major global health threats with far-reaching consequences. As outbreaks develop, the international scientific community must provide high-quality scientific research-ready biological samples to solve the existing clinical and epidemiological questions to better combat the pandemic. Such examples are provided by dedicated biobank facilities, the latter collecting increasingly high volumes of biological samples. However, the more significant concentrations of infectious or potentially infectious biological materials can create a safety risk. The current short report describes the first attempt to identify the published scientific works on biobanking and safety. Three broad thematic areas have been identified: the physical security relevant to staff and sample integrity, the data safety aspects, and the governance parameters relating to the previous two. While the current publications reflect a broad alignment with existing standards and best practices in the biobanking field, they also demonstrate an opportunity for further in-depth work on this field in the post-COVID-19 era.

摘要

传染病爆发,如“2019冠状病毒病”(COVID-19),可能构成重大的全球健康威胁,产生深远影响。随着疫情的发展,国际科学界必须提供高质量的、可供科研使用的生物样本,以解决现有的临床和流行病学问题,从而更好地抗击这一流行病。专门的生物样本库设施就是这样的例子,后者收集的生物样本数量越来越多。然而,大量集中的感染性或潜在感染性生物材料可能会带来安全风险。本简短报告介绍了首次尝试识别已发表的关于生物样本库与安全的科学著作。已确定了三个广泛的主题领域:与工作人员和样本完整性相关的物理安全、数据安全方面,以及与前两者相关的治理参数。虽然目前的出版物反映出与生物样本库领域现有标准和最佳实践的广泛一致,但它们也表明在COVID-19后时代,该领域有进一步深入研究的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87f1/8553626/7c2766daa6c5/gr1.jpg

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