老年大鼠冠状动脉去甲肾上腺素能神经支配的年龄相关变化：一项荧光组织化学研究。

Age-related changes in the noradrenergic innervation of the coronary arteries in old rats: a fluorescent histochemical study.

作者信息

Amenta F, Mione M C

机构信息

Dipartimento di Sanita' Pubblica e Biologia Cellulare, Universita' Tor Vergata, Rome, Italy.

出版信息

J Auton Nerv Syst. 1988 Apr;22(3):247-51. doi: 10.1016/0165-1838(88)90114-2.

DOI:10.1016/0165-1838(88)90114-2

PMID:3418017

Abstract

Age-related changes in the density of the noradrenergic perivascular plexus supplying the coronary vessels in the rat were studied using the glyoxylic acid fluorescence technique. A marked decrease in the density of the noradrenergic innervation of large, medium and small size coronary arteries was observed in 25-month-old rats. In contrast, the fluorescent nerves supplying the coronary veins were not decreased in old animals. The present data are indicative of an age-related reduction of fluorescent noradrenergic nerves in the rat coronary arteries.

摘要

利用乙醛酸荧光技术研究了大鼠供应冠状动脉的去甲肾上腺素能血管周围神经丛密度的年龄相关变化。在25月龄大鼠中观察到，大、中、小冠状动脉的去甲肾上腺素能神经支配密度显著降低。相比之下，老年动物中供应冠状静脉的荧光神经并未减少。目前的数据表明，大鼠冠状动脉中荧光去甲肾上腺素能神经随年龄增长而减少。