Ferrante F, Bronzetti E, Cavallotti C, Ricci A, Amenta F
Dipartimento di Scienze Neurologiche, University La Sapienza, Roma, Italy.
Mech Ageing Dev. 1990 May 15;54(1):55-61. doi: 10.1016/0047-6374(90)90015-8.
The influence of ageing on the noradrenergic innervation of the ovary was studied in female Wistar rats using high pressure liquid chromatography (HPLC) with electrochemical detection and catecholamine histofluorescence techniques. Old age was accompanied by a significant decrease in ovarian noradrenaline levels. In young animals (3-month-old) noradrenergic nerve fibres were distributed primarily to blood vessels and in lesser amounts to the interstitial glands. In aged animals (24-month-old) perivascular noradrenergic fibres were reduced by more than 40%; interstitial gland nerve fibres were reduced by approximately 20%. The possibility that impaired noradrenergic ovarian innervation occurring in old age may be in some way related with age-dependent failure in reproductive activity is discussed.
采用高压液相色谱（HPLC）电化学检测法和儿茶酚胺组织荧光技术，研究衰老对雌性Wistar大鼠卵巢去甲肾上腺素能神经支配的影响。衰老伴随着卵巢去甲肾上腺素水平的显著下降。在幼年动物（3月龄）中，去甲肾上腺素能神经纤维主要分布于血管，少量分布于间质腺。在老年动物（24月龄）中，血管周围去甲肾上腺素能纤维减少超过40%；间质腺神经纤维减少约20%。本文讨论了老年时出现的去甲肾上腺素能卵巢神经支配受损可能与生殖活动中年龄依赖性衰退存在某种关联的可能性。
