Amenta F, Bronzetti E, Ferrante F, Ricci A
Dipartimento di Scienze Neurologiche, Università La Sapienza, Roma, Italy.
Neurobiol Aging. 1990 Jan-Feb;11(1):47-50. doi: 10.1016/0197-4580(90)90061-4.
The density and pattern of the sympathetic noradrenergic innervation of the extramedullary and intramedullary blood vessels of the spinal cord was studied in 3-, 12- and 25-month-old male Wistar rats using combined catecholamine histofluorescence and quantitative image analysis techniques. The study of innervation of intramedullary vessels was accomplished in spinal cord-transected rats to avoid the interference of descending spinal monoamine fibres in the observations. No age-related changes in the density of noradrenergic innervation of the anterior spinal artery or of sympathetic fibres associated with spinal cord blood vessels occurred. These results suggest that unlike perivascular noradrenergic nerves supplying the cerebrovascular tree, the sympathetic innervation of spinal cord blood vessels does not undergo age-dependent changes. It cannot be excluded that the lesser vulnerability of the spinal compared to the cerebral vascular tree to certain kinds of age-related diseases, may depend on the unchanged sympathetic trophic regulation of spinal vessels with age.
利用儿茶酚胺组织荧光和定量图像分析技术，对3月龄、12月龄和25月龄雄性Wistar大鼠脊髓髓外和髓内血管的交感去甲肾上腺素能神经支配的密度和模式进行了研究。为避免下行脊髓单胺纤维对观察结果的干扰，在脊髓横断的大鼠中完成了对髓内血管神经支配的研究。脊髓前动脉或与脊髓血管相关的交感纤维的去甲肾上腺素能神经支配密度未出现与年龄相关的变化。这些结果表明，与供应脑血管树的血管周围去甲肾上腺素能神经不同，脊髓血管的交感神经支配不会随年龄发生变化。不能排除脊髓血管树相比于脑血管树对某些与年龄相关疾病的易感性较低，可能取决于随着年龄增长脊髓血管交感营养调节未发生改变。
