Molecular Bioscience Lab, Anvesana Research Labs, S-VYASA, Bangalore, India.
Ann Behav Med. 2022 Mar 1;56(3):235-244. doi: 10.1093/abm/kaab043.
Although yoga is found to be beneficial in the management of type 2 diabetes (T2D), its mechanism of action is poorly understood. T2D is also known to be associated with increased oxidative stress (OS) and DNA damage.
This study examines how yoga modulates OS-induced DNA damage and the efficiency of DNA repair in T2D conditions.
In this assessor-masked randomized clinical trial, T2D subjects (n = 61), aged (Mean ± SD, 50.3 ± 4.2) were randomly allocated into Yoga group (31) that received 10 weeks of yoga intervention and Control (30) with routine exercises. Molecular and biochemical assessments were done before and after the intervention period. Structural Equation Modeling using "R" was used for mediation analysis.
At the end of the 10th week, Yoga group showed significant reduction in DNA damage indicators like Tail Moment (-5.88[95%CI: -10.47 to -1.30]; P = .013) and Olive Tail Moment (-2.93[95%CI: -4.87 to -1.00]; P < .01), oxidative DNA damage marker 8-OHdG (-60.39[95%CI: -92.55 to -28.23]; P < .001) and Fasting Blood Sugar (-22.58[95%CI: -44.33 to -0.83]; P = .042) compared to Control. OGG1 protein expression indicating DNA repair, improved significantly (17.55[95%CI:1.37 to 33.73]; P = .034) whereas Total Antioxidant Capacity did not (5.80[95%CI: -0.86 to 12.47]; P = 0.086). Mediation analysis indicated that improvements in oxidative DNA damage and DNA repair together played a major mediatory role (97.4%) in carrying the effect of yoga.
The beneficial effect of yoga on DNA damage in T2D subjects was found to be mediated by mitigation of oxidative DNA damage and enhancement of DNA repair.
(www.ctri.nic.in) CTRI/2018/07/014825.
瑜伽被发现有益于 2 型糖尿病（T2D）的管理，但对其作用机制知之甚少。T2D 也与氧化应激（OS）和 DNA 损伤增加有关。
本研究旨在探讨瑜伽如何调节 T2D 条件下 OS 诱导的 DNA 损伤和 DNA 修复效率。
在这项评估员盲法随机临床试验中，将 61 名 T2D 患者（年龄：50.3±4.2 岁）随机分为瑜伽组（31 人）和对照组（30 人）。瑜伽组接受了 10 周的瑜伽干预，对照组进行常规运动。在干预前后进行分子和生化评估。使用“R”进行结构方程建模进行中介分析。
在第 10 周结束时，瑜伽组的 DNA 损伤指标如尾部矩（-5.88[95%CI：-10.47 至-1.30]；P=0.013）和橄榄尾矩（-2.93[95%CI：-4.87 至-1.00]；P<0.01）、氧化 DNA 损伤标志物 8-OHdG（-60.39[95%CI：-92.55 至-28.23]；P<0.001）和空腹血糖（-22.58[95%CI：-44.33 至-0.83]；P=0.042）均显著降低。OGG1 蛋白表达（指示 DNA 修复）显著改善（17.55[95%CI：1.37 至 33.73]；P=0.034），而总抗氧化能力没有改善（5.80[95%CI：-0.86 至 12.47]；P=0.086）。中介分析表明，氧化 DNA 损伤和 DNA 修复的改善共同在瑜伽的作用中发挥了主要的中介作用（97.4%）。
瑜伽对 T2D 患者 DNA 损伤的有益影响被发现是通过减轻氧化 DNA 损伤和增强 DNA 修复来介导的。
