纽约州与细颗粒物成分相关的帕金森病恶化。
Parkinson's disease aggravation in association with fine particle components in New York State.
机构信息
Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.
Department of Epidemiology and Neurology, Columbia University, New York, NY, USA.
出版信息
Environ Res. 2021 Oct;201:111554. doi: 10.1016/j.envres.2021.111554. Epub 2021 Jun 25.
BACKGROUND
Long-term exposure to fine particulate matter (PM) has been associated with neurodegenerative diseases, including disease aggravation in Parkinson's disease (PD), but associations with specific PM components have not been evaluated.
OBJECTIVE
To characterize the association between specific PM components and PD first hospitalization, a surrogate for disease aggravation.
METHODS
We obtained data on hospitalizations from the New York Department of Health Statewide Planning and Research Cooperative System (2000-2014) to calculate annual first PD hospitalization counts in New York State per county. We used well-validated prediction models at 1 km resolution to estimate county level population-weighted annual black carbon (BC), organic matter (OM), nitrate, sulfate, sea salt (SS), and soil particle concentrations. We then used a multi-pollutant mixed quasi-Poisson model with county-specific random intercepts to estimate rate ratios (RR) of one-year exposure to each PM component and PD disease aggravation. We evaluated potential nonlinear exposure-outcome relationships using penalized splines and accounted for potential confounders.
RESULTS
We observed a total of 197,545 PD first hospitalizations in NYS from 2000 to 2014. The annual average count per county was 212 first hospitalizations. The RR (95% confidence interval) for PD aggravation was 1.06 (1.03, 1.10) per one standard deviation (SD) increase in nitrate concentrations and 1.06 (1.04, 1.09) for the corresponding increase in OM concentrations. We also found a nonlinear inverse association between PD aggravation and BC at concentrations above the 96th percentile. We found a marginal association with SS and no association with sulfate or soil exposure.
CONCLUSION
In this study, we detected associations between the PM components OM and nitrate with PD disease aggravation. Our findings support that PM adverse effects on PD may vary by particle composition.
背景
长期暴露于细颗粒物（PM）与神经退行性疾病有关，包括帕金森病（PD）的病情加重，但尚未评估特定 PM 成分与这些疾病的关联。
目的
以 PD 的首次住院（病情加重的替代指标）为终点，评估特定 PM 成分与 PD 之间的关系。
方法
我们从纽约州卫生署全州规划和研究合作系统（2000-2014 年）获取了住院数据，以计算纽约州每个县的 PD 首次住院人数。我们使用经过充分验证的预测模型，以 1 公里的分辨率估计了县一级的黑碳（BC）、有机物（OM）、硝酸盐、硫酸盐、海盐（SS）和土壤颗粒的浓度。然后，我们使用具有县特异性随机截距的多污染物混合拟泊松模型来估计一年暴露于每种 PM 成分与 PD 病情加重的比值比（RR）。我们使用惩罚样条评估潜在的非线性暴露-结局关系，并考虑了潜在的混杂因素。
结果
我们观察到 2000 年至 2014 年期间纽约州共有 197545 例 PD 首次住院病例。每个县的年平均住院人数为 212 例。硝酸盐浓度每增加一个标准差（SD），PD 加重的 RR（95%置信区间）为 1.06（1.03，1.10），OM 浓度相应增加时 RR 为 1.06（1.04，1.09）。我们还发现 PD 加重与 BC 之间存在非线性反比关系，BC 浓度高于第 96 百分位数时尤为明显。我们发现 SS 与 PD 加重存在边缘关联，而硫酸盐和土壤暴露与 PD 加重无关联。
结论
在这项研究中，我们检测到 OM 和硝酸盐等 PM 成分与 PD 病情加重之间存在关联。我们的研究结果表明，PM 对 PD 的不良影响可能因颗粒成分而异。
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