Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Zhengzhou Road 53, Qingdao 266042, China.
Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Zhengzhou Road 53, Qingdao 266042, China.
Int J Biol Macromol. 2021 Aug 1;184:713-720. doi: 10.1016/j.ijbiomac.2021.06.155. Epub 2021 Jun 25.
Hyaluronic acid (HA) was covalently linked to the surface of bovine serum albumin/silver (BSA/Ag) porous films to fabricate a possible contact lens. The BSA/Ag/HA films showed favorable properties as contact lenses, including acceptable transparency, high water content, good hemocompatibility, non-cytotoxicity and antibacterial properties. The therapeutic potential of the BSA/Ag/HA films was evaluated on an alkali burn-induced corneal injury model on mice. The corneal healing rate was enhanced, the corneal opacification and neovascularization were lessened, and the inflammation response was reduced. The chemical cross-linking of HA on the films prolonged the retention time of HA on the corneal surface, thus enhanced the drug efficacy and improved the patient compliance, proving the high potential of BSA/Ag/HA films as contact lenses.
透明质酸（HA）被共价键合到牛血清白蛋白/银（BSA/Ag）多孔膜的表面，以制备一种潜在的隐形眼镜。BSA/Ag/HA 膜作为隐形眼镜具有良好的性能，包括可接受的透明度、高含水量、良好的血液相容性、无细胞毒性和抗菌性能。在小鼠碱烧伤诱导的角膜损伤模型上评估了 BSA/Ag/HA 膜的治疗潜力。角膜愈合率提高，角膜混浊和新生血管形成减少，炎症反应减轻。HA 在膜上的化学交联延长了 HA 在角膜表面的保留时间，从而增强了药物疗效，提高了患者的顺应性，证明了 BSA/Ag/HA 膜作为隐形眼镜的巨大潜力。
