Schreiber Jane E, Cole Joanna C M, Houtrow Amy J, Kallan Michael J, Thom Elizabeth A, Howell Lori J, Adzick N Scott
Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Fetal Diagn Ther. 2021;48(6):479-484. doi: 10.1159/000516602. Epub 2021 Jun 28.
Depressive risk is higher for mothers of infants with chronic medical conditions. The present study examined maternal depressive risk and associations with parent and child outcomes among mothers of young children who were randomized to either prenatal or postnatal surgical closure for myelomeningocele.
Using the Management of Myelomeningocele Study database, maternal depressive risk was examined at 3 time points as follows: prior to birth, 12 months, and 30 months post birth. Separate multivariate analyses examined associations among change in depressive risk (between baseline and 30 months), parenting stress, and child outcomes at 30 months.
Mean scores were in the minimal depressive risk range at all the time points. Post birth depressive risk did not differ by prenatal versus postnatal surgery. Mean change scores reflected a decrease in depressive risk during the first 30 months. Only 1.1-4.5% of mothers reported depressive risk in the moderate to severe range across time points. Increased depressive risk during the first 30 months was associated with increased parenting stress scores and slightly lower child cognitive scores at 30 months.
Most mothers reported minimal depressive risk that decreased over time, regardless of whether their infant underwent prenatal or postnatal surgery. Only a small percentage of mothers endorsed moderate to severe depressive risk, but an increase in depressive risk over time was associated with higher parental stress and slightly lower child cognitive development.
患有慢性疾病婴儿的母亲患抑郁症的风险更高。本研究调查了患有脊髓脊膜膨出症的幼儿母亲的抑郁风险,以及其与父母和孩子结局之间的关联,这些母亲被随机分配接受产前或产后手术闭合治疗。
利用脊髓脊膜膨出症管理研究数据库,在三个时间点对母亲的抑郁风险进行了调查,具体如下:出生前、出生后12个月和出生后30个月。分别进行多变量分析,以研究抑郁风险变化(基线至30个月之间)、育儿压力和30个月时孩子结局之间的关联。
在所有时间点,平均得分均处于最低抑郁风险范围内。产后抑郁风险在产前手术与产后手术之间并无差异。平均变化得分反映出在最初30个月内抑郁风险有所降低。在各个时间点,只有1.1%-4.5%的母亲报告有中度至重度抑郁风险。最初30个月内抑郁风险增加与育儿压力得分增加以及30个月时孩子认知得分略低有关。
大多数母亲报告的抑郁风险最低,且随时间降低,无论其婴儿接受的是产前手术还是产后手术。只有一小部分母亲认可中度至重度抑郁风险,但随着时间推移抑郁风险增加与更高的父母压力以及略低的孩子认知发展有关。