Ignarro Louis J
Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Center for the Health Sciences, Los Angeles, CA 90095 (USA), Fax: (+1) 310-825-6267.
Angew Chem Int Ed Engl. 1999 Jul 12;38(13-14):1882-1892. doi: 10.1002/(SICI)1521-3773(19990712)38:13/14<1882::AID-ANIE1882>3.0.CO;2-V.
"Endothelium-derived relaxing factor (EDRF) must be nitric oxide." Although there was much experimental evidence that effects on or actions of EDRF were identical to those of nitric oxide, proposing this hypothesis certainly meant going out on a limb. However, once this discovery was made increased investigation indicated the physiological significance of nitric oxide in vascular biology.
“内皮源性舒张因子（EDRF）必定是一氧化氮。”尽管有大量实验证据表明EDRF的作用与一氧化氮的作用相同，但提出这一假设无疑意味着冒险行事。然而，这一发现一旦做出，更多的研究便揭示了一氧化氮在血管生物学中的生理意义。
