Murad Ferid
Department of Integrative Biology, Pharmacology and Physiology, University of Texas-Houston Medical School, P.O. Box 20708, Houston, TX 77225 (USA), Fax: (+1) 713-500-7444.
Angew Chem Int Ed Engl. 1999 Jul 12;38(13-14):1856-1868. doi: 10.1002/(SICI)1521-3773(19990712)38:13/14<1856::AID-ANIE1856>3.0.CO;2-D.
A unique simple molecule with an array of signaling functions: NO. The free radical nitric oxide not only mediates a long list of biological effects by activating guanylyl cyclase and increasing cyclic GMP synthesis from GTP, but can also interact with transition metals such as iron, thiol groups, other free radicals, oxygen, superoxide anion, unsaturated fatty acids, and other molecules. Furthermore, NO can function as an intracellular messenger, an autacoid, a paracrine substance, a neurotransmitter, or a hormone that can be carried to distant sites for effects.
一氧化氮。自由基一氧化氮不仅通过激活鸟苷酸环化酶并增加从鸟苷三磷酸合成环磷酸鸟苷来介导一系列生物学效应，还能与过渡金属如铁、巯基、其他自由基、氧、超氧阴离子、不饱和脂肪酸及其他分子相互作用。此外，一氧化氮可作为细胞内信使、自分泌物质、旁分泌物质、神经递质或一种可被携带至远处发挥作用的激素。
