微电极阵列、二羟基化和正交安全夹连接子的开发。
Microelectrode Arrays, Dihydroxylation, and the Development of an Orthogonal Safety-Catch Linker.
机构信息
Washington University in Saint Louis, Saint Louis, Missouri 63130, United States.
出版信息
Org Lett. 2021 Jul 16;23(14):5440-5444. doi: 10.1021/acs.orglett.1c01675. Epub 2021 Jun 29.
Abstract
Construction of larger molecular libraries on an addressable microelectrode array requires a method for recovering and characterizing molecules from the surface of any electrode in the array. This method must be orthogonal to the synthetic strategies needed to build the array. We report here a method for achieving this goal that employs the site-selective dihydroxylation reaction of a simple olefin.
摘要
在可寻址微电极阵列上构建更大的分子库需要一种从阵列中任何电极表面回收和表征分子的方法。该方法必须与构建阵列所需的合成策略正交。我们在这里报告了一种实现这一目标的方法，该方法采用了简单烯烃的选择性双羟基化反应。
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Introduction to Microelectrode Arrays, the Site-Selective Functionalization of Electrode Surfaces, and the Real-Time Detection of Binding Events.微电极阵列简介、电极表面的位点选择性功能化以及结合事件的实时检测
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Microelectrode arrays: a general strategy for using oxidation reactions to site selectively modify electrode surfaces.微电极阵列：一种利用氧化反应进行选择性修饰电极表面的通用策略。
Langmuir. 2014 Mar 4;30(8):2280-6. doi: 10.1021/la404895b. Epub 2014 Feb 18.
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Site-selectively functionalizing microelectrode arrays: the use of Cu(I)-catalysts.选择性功能化微电极阵列：Cu（I）催化剂的应用。
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