Zhejiang Academy of Science and Technology Information, Hangzhou, China.
School of Medicine, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
Hum Vaccin Immunother. 2021 Nov 2;17(11):4374-4382. doi: 10.1080/21645515.2021.1947100. Epub 2021 Jun 29.
Chimeric antigen receptors-based cell therapies have shown impressive preclinical and clinical success and revolutionized biomedicine. However, the link between science and invention, the impact of international cooperation, and the influence and prestige of CARs research have not been explored. This study analyzed the landscape of peer-reviewed articles and patents related to CARs. A total of 5,681 publications were analyzed using bibliometrics and machine learning-based text mining to assess publication metrics, subject areas, and research hotspots. 5,010 Inpadoc families were also analyzed for patent filing trends, priority countries, and applicant and inventor rankings. The results show that CARs research has the following distinctive features: high research prestige among research community; strong global geographical bias in both academic output and patenting patterns; strong links between science and invention, but significant differences among countries; and an inverse relationship between country size and international collaboration rates.
嵌合抗原受体细胞疗法在临床前和临床方面取得了令人瞩目的成功，彻底改变了生物医学领域。然而，科学与发明之间的联系、国际合作的影响以及 CAR 研究的影响力和声望尚未得到探索。本研究分析了与 CAR 相关的同行评审文章和专利的全景。利用文献计量学和基于机器学习的文本挖掘分析了 5681 篇出版物，以评估出版物指标、主题领域和研究热点。还分析了 5010 个 Inpadoc 家族的专利申请趋势、优先国家、申请人和发明人排名。结果表明，CAR 研究具有以下显著特征：在研究界具有很高的研究声望；学术产出和专利模式都存在强烈的全球地域偏见；科学与发明之间联系紧密，但各国之间存在显著差异；国家规模与国际合作率呈反比关系。
