Evidence Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, PR China.
Key Laboratory of Evidence-Based Medicine & Knowledge Translation of Gansu Province, Lanzhou 730000, PR China.
Future Oncol. 2020 Apr;16(10):597-612. doi: 10.2217/fon-2019-0810. Epub 2020 Mar 24.
Our study aimed to analyze the characteristics of papers published on CAR T-cell in the field of cancer and explore the existing hot topics and prospects. We explored the global hotspots and future prospects regarding CAR T-cell therapy in cancer research. Papers of CAR T-cell research were retrieved from the Web of Science database. Analysis was performed using VOSviewer, CiteSpace and Excel software. A total number of 1994 papers related to CAR T-cell research of cancer were included. published the most papers (n = 85, 4.26%). A total of 9792 authors participated in the publication of all papers. 62 countries and 2065 institutions have participated in the publication of all papers. Research trends are to improve the immunosuppressive microenvironment of cancer, optimize the structure of CAR T-cells and develop 'super CAR T-cell' by using gene-editing technology.
我们的研究旨在分析癌症领域中 CAR T 细胞相关论文的特点，并探讨现有热点和未来前景。我们探讨了癌症研究中 CAR T 细胞治疗的全球热点和未来前景。从 Web of Science 数据库中检索了 CAR T 细胞研究论文。使用 VOSviewer、CiteSpace 和 Excel 软件进行分析。共纳入了 1994 篇与癌症 CAR T 细胞研究相关的论文。美国发表的论文最多（n=85，4.26%）。共有 9792 位作者参与了所有论文的发表。共有 62 个国家和 2065 个机构参与了所有论文的发表。研究趋势是改善癌症的免疫抑制微环境，通过基因编辑技术优化 CAR T 细胞的结构并开发“超级 CAR T 细胞”。
