“原始抗原性失误”是否使印度的新冠疫苗接种行动复杂化？
Is 'original antigenic sin' complicating indian vaccination drive against Covid-19?
机构信息
Department of Pediatrics, Mangla Hospital & Research Center, Bijnor, India.
出版信息
Hum Vaccin Immunother. 2021 Oct 3;17(10):3314-3315. doi: 10.1080/21645515.2021.1945904. Epub 2021 Jun 29.
Abstract
India is in the grip of a devastating second wave of Covid-19. Many experts believe new variants of concern (VOC) are behind this unprecedented surge. Some media reports are hinting toward higher risk of Covid infection following Covid vaccinations. 'Original antigenic sin,' in which a prior exposure to an antigen leads to an ineffective response to a related antigen, may offer one immunological explanation for this unusual association. There is an urgent need of undertaking a detailed study to prove/disprove this association.
摘要
印度正遭受第二波毁灭性的新冠疫情冲击。许多专家认为，新的关切变种（VOC）是造成这波前所未有的疫情激增的原因。一些媒体报道暗示，接种新冠疫苗后，感染新冠的风险可能会增加。“原始抗原原罪”，即先前接触一种抗原会导致对相关抗原的无效反应，可能为这种不寻常的关联提供了一种免疫学解释。现在迫切需要进行一项详细的研究来证明/反驳这种关联。
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