Pillai Shiv
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, 02139, USA.
Trends Immunol. 2022 Apr;43(4):271-273. doi: 10.1016/j.it.2022.02.009. Epub 2022 Feb 28.
According to Röltgen and colleagues vaccination generates antibody breadth, whereas SARS-CoV-2 infection does not. Vaccination results in germinal center B cell responses and generates immunological breadth, with antibodies that bind viral variants. COVID-19 from SARS-CoV-2 infection does not induce germinal centers; it sustains immune imprinting, also known as 'original antigenic sin', and this results in limited immunological breadth.
根据勒尔特根及其同事的研究，接种疫苗可产生抗体广度，而感染新冠病毒则不会。接种疫苗会引发生发中心B细胞反应并产生免疫广度，所产生的抗体可结合病毒变体。新冠病毒感染所致的新冠肺炎不会诱导生发中心形成；它会维持免疫印记，即所谓的“原始抗原罪”，这会导致免疫广度有限。
