From the Department of Anesthesia and Critical Care (Farsi, Bahaaziq, Abushoshah, Boker), Faculty of Medicine, King Abdulaziz University; from the Special Infectious Agents Unit (Alandijany, El-Kafrawy, Alsayed, Azhar), King Fahd Medical Research Center, King Abdulaziz University; from the Department of Medical Laboratory Technology (Alandijany, El-Kafrawy, Alsayed, Azhar), Faculty of Applied Medical Sciences, King Abdulaziz University; from the Department of Hematology (Radwi), College of Medicine, University of Jeddah; from the Department of Surgery (Farsi), Faculty of Medicine, King Abdulaziz University Jeddah; from the Clinical Skills and Simulation Center (Boker), King Abdulaziz University, Jeddah; and from the Department of Nursing (Alsayed), Faculty of Al-Qunfudah Health Sciences, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia.
Saudi Med J. 2021 Jul;42(7):742-749. doi: 10.15537/smj.2021.42.7.20210348.
To identify the prevalence of COVID-19 antibodies among operating room and critical care staff.
In this cross-sectional study, we recruited 319 Healthcare workers employed in the operation theater and intensive care unit of King Abdulaziz University Hospital (KAUH), a tertiary teaching hospital in Jeddah, Saudi Arabia between August 9, 2020 and November 2, 2020. All participants completed a 20-item questionnaire on demographic data and COVID-19 risk factors and provided blood samples. Antibody testing was performed using an in-house enzyme immunoassay and microneutralization test.
Of the 319 participants, 39 had detectable COVID-19 antibodies. Five of them had never experienced any symptoms suggestive of COVID-19, and only 19 were previously diagnosed with COVID-19. The odds of developing COVID-19 or having corresponding antibodies increased if participants experienced COVID-19 symptoms (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.2-7.5) or reported contact with an infected family member (OR, 5.3; 95% CI, 2.5-11.2). Disease acquisition was not associated with employment in the ICU and involvement in the intubation of or close contact with COVID-19 patients. Of the 19 previously diagnosed participants, 6 did not possess any detectable COVID-19 antibodies.
Healthcare workers may have undiagnosed COVID-19, and those previously infected may not have long-lasting immunity. Therefore, hospitals must continue to uphold strict infection control during the COVID-19 pandemic.
确定手术室和重症监护病房医护人员中 COVID-19 抗体的流行情况。
在这项横断面研究中，我们招募了 319 名在沙特阿拉伯吉达的阿卜杜勒阿齐兹国王大学医院（KAUH）手术室和重症监护病房工作的医护人员，他们于 2020 年 8 月 9 日至 11 月 2 日期间完成了一份包含人口统计学数据和 COVID-19 危险因素的 20 项问卷，并提供了血液样本。使用内部酶联免疫吸附试验和微量中和试验进行抗体检测。
在 319 名参与者中，有 39 人可检测到 COVID-19 抗体。其中 5 人从未经历过任何提示 COVID-19 的症状，只有 19 人之前被诊断为 COVID-19。如果参与者出现 COVID-19 症状（比值比 [OR]，3.1；95%置信区间 [CI]，1.2-7.5）或报告与感染的家庭成员接触（OR，5.3；95% CI，2.5-11.2），则感染 COVID-19 或产生相应抗体的可能性会增加。疾病的获得与在 ICU 工作以及参与 COVID-19 患者的插管或密切接触无关。在之前被诊断为 COVID-19 的 19 名参与者中，有 6 名没有任何可检测到的 COVID-19 抗体。
医护人员可能患有未确诊的 COVID-19，而那些之前感染过的人可能没有持久的免疫力。因此，医院在 COVID-19 大流行期间必须继续坚持严格的感染控制。
