Mushcab Hayat, Al-Tawfiq Jaffar A, Ghamdi Mohammed, Babgi Amani, Amir Abdulrazack, Sheikh Salwa S, Darwisheh Adel, Alobaid Abrar, Jebakumar Arulanantham Zechariah, Qahtani Saeed, Al Sagheir Ahmed
Research Office, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia.
Infectious Disease Unit - Specialty Internal Medicine, and Quality and Patient Safety Department, Johns Hopkins Aramco Healthcare, Dhahran, Eastern Province, Saudi Arabia.
Infect Drug Resist. 2022 Aug 10;15:4393-4406. doi: 10.2147/IDR.S369755. eCollection 2022.
The nature of the healthcare workers' jobs standing at the frontline against the coronavirus disease 2019 (COVID-19) puts them at a higher risk of unknowingly contracting the disease and potentially contributing to the spread. This study aims to assess the overall positive seroconversion prevalence of SARS-CoV-2.
This is a longitudinal cohort study of healthcare workers at Johns Hopkins Aramco Healthcare (JHAH). JHAH is a tertiary hospital located in Dhahran serving patients in several districts in the Eastern Province of Saudi Arabia. Participants were recruited between June and December 2020. Each participant had a serology blood test and completed the World Health Organization's risk factor assessment questionnaire.
This study included 682 participants working in JHAH, representing 15.7% of our population. Out of the 682 participants, 15.2% had a positive SARS-CoV-2 rt-PCR before taking part in the study. However, only 87 tested positive for SARS-CoV-2 antibodies, a prevalence of 12.7% of all participants. Out of the 87 positives for SARS-CoV-2 antibodies, 17 participants never tested positive for COVID-19 rt-PCR, a prevalence of 2.9%. Moreover, not properly using alcohol-based hand rub or soap and water after the risk of body fluid exposure and wearing personal protective equipment when indicated were found to be statistically significant to having a positive SARS-CoV-2 IgG assay.
Positive seroconversion rate was considerably low during the first wave of COVID-19 amongst JHAH's healthcare workers and similar to other healthcare organizations in Saudi Arabia. Seropositivity correlated significantly with following infection prevention and control recommendations.
NCT04469647.
医护人员站在抗击2019冠状病毒病（COVID-19）的前线，其工作性质使他们在不知不觉中感染该疾病并可能导致传播的风险更高。本研究旨在评估严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的总体血清阳转率。
这是一项针对约翰霍普金斯阿美医疗集团（JHAH）医护人员的纵向队列研究。JHAH是一家位于达兰的三级医院，为沙特阿拉伯东部省份多个地区的患者提供服务。研究对象于2020年6月至12月招募。每位参与者都进行了血清学血液检测，并完成了世界卫生组织的风险因素评估问卷。
本研究纳入了682名在JHAH工作的参与者，占我们研究人群的15.7%。在这682名参与者中，15.2%在参加研究前SARS-CoV-2逆转录聚合酶链反应（rt-PCR）呈阳性。然而，只有87人SARS-CoV-2抗体检测呈阳性，占所有参与者的12.7%。在87名SARS-CoV-2抗体阳性者中，17名参与者COVID-19 rt-PCR从未呈阳性，患病率为2.9%。此外，发现体液暴露风险后未正确使用含酒精洗手液或肥皂和水以及在需要时佩戴个人防护装备与SARS-CoV-2免疫球蛋白G（IgG）检测呈阳性在统计学上具有显著相关性。
在COVID-19第一波疫情期间，JHAH医护人员的血清阳转率相当低，与沙特阿拉伯的其他医疗机构相似。血清阳性与遵循感染预防和控制建议显著相关。
NCT04469647。
