Department of Radiology, A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, 02139, USA.
Sci Rep. 2021 Jun 29;11(1):13456. doi: 10.1038/s41598-021-92644-8.
Breast-conserving surgery (BCS) is a commonly utilized treatment for early stage breast cancers but has relatively high reexcision rates due to post-surgical identification of positive margins. A fast, specific, sensitive, easy-to-use tool for assessing margins intraoperatively could reduce the need for additional surgeries, and while many techniques have been explored, the clinical need is still unmet. We assess the potential of Magnetic Particle Imaging (MPI) for intraoperative margin assessment in BCS, using a passively or actively tumor-targeted iron oxide agent and two hardware devices: a hand-held Magnetic Particle detector for identifying residual tumor in the breast, and a small-bore MPI scanner for quickly imaging the tumor distribution in the excised specimen. Here, we present both hardware systems and demonstrate proof-of-concept detection and imaging of clinically relevant phantoms.
保乳手术（BCS）是一种常用于早期乳腺癌的治疗方法，但由于术后发现阳性边缘，其再次切除率相对较高。一种快速、特异、敏感、易于使用的术中评估切缘的工具可以减少额外手术的需要，尽管已经探索了许多技术，但临床需求仍未得到满足。我们评估了磁性粒子成像（MPI）在保乳手术中用于术中切缘评估的潜力，使用了一种被动或主动肿瘤靶向氧化铁剂和两种硬件设备：一种手持式磁性粒子探测器，用于识别乳房中的残留肿瘤，以及一种小口径 MPI 扫描仪，用于快速成像切除标本中的肿瘤分布。在这里，我们展示了这两种硬件系统，并证明了临床相关模型的探测和成像的概念验证。
