鸡胃蛋白酶原激活的第一步与凝乳酶原的激活步骤相似。
The first step in the activation of chicken pepsinogen is similar to that of prochymosin.
作者信息
Keilova H, Kostka V, Kay J
出版信息
Biochem J. 1977 Dec 1;167(3):855-8. doi: 10.1042/bj1670855.
Abstract
Chicken pepsinogen was incubated at pH2.5 with pepstatin. The zymogen activated itself by a sequential mechanism and an intact peptide derived from residues 1-26 in the protein was released in the first step. This peptide was found to inhibit the milk-clotting activities of pig and chicken pepsins and calf chymosin but to different extents.
摘要
将鸡胃蛋白酶原在pH2.5条件下与胃蛋白酶抑制剂一起温育。该酶原通过一种连续机制自我激活，并且在第一步中释放出一种源自该蛋白质1 - 26位残基的完整肽段。发现这种肽对猪和鸡胃蛋白酶以及小牛凝乳酶的凝乳活性均有抑制作用，但程度不同。
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