胃蛋白酶原转化为胃蛋白酶不是一个一步完成的过程。
Conversion of pepsinogen into pepsin is not a one-step process.
作者信息
Dykes C W, Kay J
出版信息
Biochem J. 1976 Jan 1;153(1):141-4. doi: 10.1042/bj1530141.
Abstract
By incubation of pepsinogen with pepstatin at pH2.5, the first 'active' protein generated on activation is trapped in an inactive complex. The first activation peptide liberated has been identified as residues 1-16 from the pepsinogen sequence. This suggests a sequential mechanism rather than a one-step formation of pepsin.
摘要
通过在pH2.5条件下将胃蛋白酶原与胃蛋白酶抑制剂一起温育，激活时产生的首个“活性”蛋白被困在无活性复合物中。释放出的首个激活肽已被鉴定为胃蛋白酶原序列中的第1-16位残基。这表明是一种顺序机制，而非胃蛋白酶的一步形成机制。
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