Alter M J, Favero M S, Miller J K, Coleman P J, Bland L A
Hepatitis Branch, Centers for Disease Control, Atlanta, GA 30333.
JAMA. 1988 Oct 14;260(14):2073-6. doi: 10.1001/jama.260.14.2073.
In 1986, the Centers for Disease Control, in collaboration with the Health Care Financing Administration, surveyed 1350 chronic hemodialysis centers in the United States to ascertain practices associated with the reuse of disposable hemodialyzers and the frequency of pyrogenic reactions and septicemia among patients. Reuse of hemodialyzers was reported by 63% of the centers. Centers that used RenNew-D (n = 5) for reprocessing hemodialyzers, compared with centers that did not reuse (n = 495), were more likely to report pyrogenic reactions (60% vs 13%) and episodes of septicemia (100% vs 55%) among their patients. Reusing hemodialyzers more than 20 times and, in some instances, also using manual reprocessing systems was significantly associated with clustering of pyrogenic reactions regardless of the type of germicide used. To detect membrane leaks developing after multiple reuses, air-pressure-leak tests should be performed on all reprocessed hemodialyzers.
1986年，疾病控制中心与医疗保健财务管理局合作，对美国1350家慢性血液透析中心进行了调查，以确定与一次性血液透析器复用相关的做法以及患者中热原反应和败血症的发生频率。63%的中心报告了血液透析器的复用情况。与未复用的中心（n = 495）相比，使用RenNew-D（n = 5）对血液透析器进行再处理的中心更有可能报告其患者中出现热原反应（60%对13%）和败血症发作（100%对55%）。无论使用何种类型的杀菌剂，血液透析器复用超过20次，在某些情况下还使用手动再处理系统，均与热原反应的聚集显著相关。为了检测多次复用后出现的膜泄漏，应对所有再处理后的血液透析器进行气压泄漏测试。
