Tlili Ghassen, Ammar Houssem, Majdoub Wiem, Dziri Sonia, Farhat Waad, Acacha Emir, Gupta Rahul, Jalleli Najmeddine, Azzabi Awatef, Jaidane Mehdi
Department of Urology, Sahloul Hospital, Sousse, Tunisia.
Department of Gastrointestinal Surgery, Sahloul Hospital, Sousse, Tunisia.
Ann Med Surg (Lond). 2021 Jun 6;67:102475. doi: 10.1016/j.amsu.2021.102475. eCollection 2021 Jul.
Neuroendocrine carcinomas of the urinary bladder are rare tumors, estimated at less than 1% of urinary bladder malignancies. They are mainly represented by small cell neuroendocrine carcinoma, while large cell neuroendocrine carcinoma (LCNEC) is rarely reported.
We report a case of a 49-year-old man presenting paraplegia caused by a metastatic urinary bladder LCNEC, which was managed with palliative external beam radiotherapy (EBRT) associated with MVAC chemotherapy, including methotrexate, vinblastine sulfate, doxorubicin hydrochloride (Adriamycin), and cisplatin. At the last follow-up of one year after his admission, there was a symptomatic improvement in the pain intensity.
LCNEC of the bladder was first described in 1986, and, until now, less than 40 cases have been published in the literature. To the best of our knowledge, this is the first case of primary LCNEC of the urinary bladder presenting with paraplegia.
膀胱神经内分泌癌是罕见肿瘤，估计占膀胱恶性肿瘤的比例不到1%。它们主要由小细胞神经内分泌癌代表，而大细胞神经内分泌癌（LCNEC）鲜有报道。
我们报告一例49岁男性，因转移性膀胱LCNEC导致截瘫，采用姑息性体外照射放疗（EBRT）联合MVAC化疗进行治疗，MVAC化疗包括甲氨蝶呤、硫酸长春碱、盐酸多柔比星（阿霉素）和顺铂。入院后一年的最后一次随访时，疼痛强度有了症状改善。
膀胱LCNEC于1986年首次被描述，截至目前，文献报道的病例不到40例。据我们所知，这是首例出现截瘫的原发性膀胱LCNEC病例。
