Hamilton Amanda, Jayaratne Prasad, Zonta Mark
Townsville University Hospital, Townsville, QLD, Australia.
Sullivan Nicolaides Pathology, Mater Hospital Pimlico, Townsville, QLD, Australia.
SAGE Open Med Case Rep. 2021 Jun 16;9:2050313X211023685. doi: 10.1177/2050313X211023685. eCollection 2021.
Merkel cell carcinoma (MCC) and malignant melanoma are aggressive skin cancers that usually arise in sun-exposed parts of the body. This report describes an 85-year-old man who underwent a wide local excision and sentinel lymph node biopsy for primary MCC and was subsequently found to have metastatic MCC and malignant melanoma within the left inguinal sentinel lymph node. Dual diagnoses of aggressive cutaneous carcinomas, although rare, may become more common in regions of high ultraviolet exposure and an ageing population. Currently, there are no guidelines for treating synchronous MCC and melanoma, however, immunotherapy with PD-1 inhibitors and anti-CTLA-4 receptor antagonists have shown therapeutic effect against these two cancers and should be considered in treatment planning.
默克尔细胞癌（MCC）和恶性黑色素瘤是侵袭性皮肤癌，通常发生在身体暴露于阳光下的部位。本报告描述了一名85岁男性，因原发性MCC接受了广泛局部切除和前哨淋巴结活检，随后在前哨淋巴结中发现了转移性MCC和恶性黑色素瘤。侵袭性皮肤癌的双重诊断虽然罕见，但在紫外线暴露高的地区和老龄化人群中可能会变得更加常见。目前，尚无治疗同步性MCC和黑色素瘤的指南，然而，PD-1抑制剂和抗CTLA-4受体拮抗剂的免疫疗法已显示出对这两种癌症的治疗效果，在治疗方案规划中应予以考虑。
