College of Materials Science and Engineering, Hunan University, Changsha, 410082, P. R. China.
Centre for Materials Science and School of Chemistry and Physics, Queensland University of Technology (QUT), Brisbane, 4000, Australia.
Adv Sci (Weinh). 2021 Aug;8(16):e2101184. doi: 10.1002/advs.202101184. Epub 2021 Jun 30.
Nanomaterials having enzyme-like activities are recognized as potentially important self-therapeutic nanomedicines. Herein, a peroxidase-like artificial enzyme is developed based on novel biodegradable boron oxynitride (BON) nanostructures for highly efficient and multi-mode breast cancer therapies. The BON nanozyme catalytically generates cytotoxic hydroxyl radicals, which induce apoptosis of 4T1 cancer cells and significantly reduce the cell viability by 82% in 48 h. In vivo experiment reveals a high potency of the BON nanozyme for breast tumor growth inhibitions by 97% after 14-day treatment compared with the control, which are 10 times or 1.3 times more effective than the inert or B-releasing boron nitride (BN) nanospheres, respectively. This work highlights the BON nanozyme and its functional integrations within the BN nanomedicine platform for high-potency breast cancer therapies.
具有酶样活性的纳米材料被认为是潜在的重要自疗纳米药物。在此，基于新型可生物降解的硼氧氮化物 (BON) 纳米结构，开发了一种过氧化物酶样人工酶，用于高效多模式乳腺癌治疗。BON 纳米酶催化产生细胞毒性羟自由基，诱导 4T1 癌细胞凋亡，并在 48 小时内将细胞活力显著降低 82%。体内实验表明，与对照组相比，经过 14 天治疗后，BON 纳米酶对乳腺肿瘤生长的抑制作用高达 97%，分别比惰性或硼释放氮化硼 (BN) 纳米球高 10 倍或 1.3 倍。这项工作突出了 BON 纳米酶及其在 BN 纳米医学平台内的功能整合，用于高效的乳腺癌治疗。
