School of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Ningxia Collaborative Innovation Center of Regional Characteristic Traditional Chinese Medicine, Yinchuan 750004, China.
J Pharm Pharmacol. 2021 Dec 7;73(12):1571-1591. doi: 10.1093/jpp/rgab141.
Dictamnus dasycarpus is a plant of the Rutaceae family, and its root bark is the main part used as a medicine, named 'Bai-Xian-Pi'. It is used to clear away heat, remove dampness, and dispel wind and also used for detoxification. The purpose of this review is to provide a systematic review about the botany, traditional uses, phytochemistry, pharmacology and toxicology of this plant.
More than 200 compounds have been isolated and identified from the plant, including alkaloids and their glycosides, terpenoids and their derivatives and phenylpropanoids. Extensive pharmacological activities of the extracts or compounds of D. dasycarpus in vivo and in vitro were mainly confirmed, including anti-inflammatory activity, protecting cardiovascular activity, improving liver injury and anti-cancer activity.
In this paper, the botany, traditional uses, phytochemistry and pharmacology of D. dasycarpus were reviewed. In the future, D. dasycarpus needs further study, such as paying more attention to quality control and the utilization on agriculture. In addition, discussing the medicinal components of decoction as well as the toxicity will also contribute to the progress of clinical trial studies.
白鲜皮是芸香科植物白鲜的干燥根皮，具有清热燥湿、祛风解毒之功效。本研究旨在对该植物的植物学、传统用途、化学成分、药理学和毒理学进行系统综述。
从该植物中已分离鉴定出 200 多种化合物，包括生物碱及其糖苷、萜类及其衍生物和苯丙素类化合物。D. dasycarpus 的提取物或化合物在体内和体外均具有广泛的药理活性，主要包括抗炎活性、保护心血管活性、改善肝损伤和抗癌活性。
本文对白鲜皮的植物学、传统用途、化学成分和药理学进行了综述。未来，D. dasycarpus 需要进一步研究，例如更加关注质量控制和农业利用。此外，讨论汤剂的药用成分以及毒性也将有助于临床试验研究的进展。
