Liu Hongxu, Lionello Chiara, Westley Jenna, Cardellini Annalisa, Huynh Uyen, Pavan Giovanni M, Thayumanavan S
Department of Chemistry, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA.
Department of Applied Science and Technology, Politecnico di Torino, 10129 Torino, Italy.
Nanoscale. 2021 Jul 8;13(26):11568-11575. doi: 10.1039/d1nr02000e.
Understanding the molecular rules behind the dynamics of supramolecular assemblies is fundamentally important for the rational design of responsive assemblies with tunable properties. Herein, we report that the dynamics of temperature-sensitive supramolecular assemblies is not only affected by the dehydration of oligoethylene glycol (OEG) motifs, but also by the thermally-promoted molecular motions. These counteracting features set up a dynamics transition point (DTP) that can be modulated with subtle variations in a small hydrophobic patch on the hydrophilic face of the amphiphilic assembly. Understanding the structural factors that control the dynamics of the assemblies leads to rational design of enzyme-responsive assemblies with tunable temperature responsive profiles.
理解超分子组装体动力学背后的分子规则对于合理设计具有可调性质的响应性组装体至关重要。在此，我们报道温度敏感型超分子组装体的动力学不仅受低聚乙二醇（OEG）基序脱水的影响，还受热促进的分子运动影响。这些相互抵消的特性建立了一个动力学转变点（DTP），该点可通过两亲性组装体亲水面上一个小疏水区域的细微变化进行调节。理解控制组装体动力学的结构因素有助于合理设计具有可调温度响应曲线的酶响应性组装体。
