Cho Yukio, Christoff-Tempesta Ty, Kaser Samuel J, Ortony Julia H
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Soft Matter. 2021 Jun 28;17(24):5850-5863. doi: 10.1039/d1sm00047k. Epub 2021 Jun 11.
Self-assembly of amphiphilic small molecules in water leads to nanostructures with customizable structure-property relationships arising from their tunable chemistries. Characterization of these assemblies is generally limited to their static structures -e.g. their geometries and dimensions - but the implementation of tools that provide a deeper understanding of molecular motions has recently emerged. Here, we summarize recent reports showcasing dynamics characterization tools and their application to small molecule assemblies, and we go on to highlight supramolecular systems whose properties are substantially affected by their conformational, exchange, and water dynamics. This review illustrates the importance of considering dynamics in rational amphiphile design.
两亲性小分子在水中的自组装会形成具有可定制结构-性质关系的纳米结构，这源于它们可调节的化学性质。对这些组装体的表征通常局限于其静态结构，例如它们的几何形状和尺寸，但最近出现了一些能够更深入理解分子运动的工具。在这里，我们总结了近期展示动力学表征工具及其在小分子组装体中的应用的报告，并继续强调其性质会受到构象、交换和水动力学显著影响的超分子体系。这篇综述阐述了在合理设计两亲分子时考虑动力学的重要性。
