HIV 感染儿童和青少年的握力与骨量参数之间的关系。一项横断面研究。
Association between handgrip strength and bone mass parameters in HIV-infected children and adolescents. A cross-sectional study.
机构信息
MSc. Doctoral Student, Department of Physical Education, Universidade Federal de Santa Catarina (UFSC), Florianópolis (SC), Brazil.
PhD. Adjunct Professor, Instituto de Educação Física e Esporte (IEFE), Universidade Federal de Alagoas (UFAL), Maceió (AL), Brazil.
出版信息
Sao Paulo Med J. 2021 Jul-Aug;139(4):405-411. doi: 10.1590/1516-3180.2020.0539.R1.090321.
BACKGROUND
Low bone mineral content (BMC) and bone mineral density (BMD) have been identified in human immunodeficiency virus (HIV)-infected children and adolescents. The direct adverse effects of HIV infection and combined antiretroviral therapy (ART) negatively contribute to bone metabolism. A direct relationship between muscle strength levels and BMD in HIV-infected adults and older adults has been described. However, it is unknown whether handgrip strength (HGS) is associated with bone mass in pediatric populations diagnosed with HIV.
OBJECTIVE
To ascertain whether HGS levels are associated with BMC and BMD in HIV-infected children and adolescents.
DESIGN AND SETTING
Cross-sectional study conducted in Florianãpolis, Brazil, in 2016.
METHODS
The subjects were 65 children and adolescents (8-15 years) diagnosed with vertically-transmitted HIV. Subtotal and lumbar-spine BMC and BMD were obtained via dual-emission X-ray absorptiometry (DXA). HGS was measured using manual dynamometers. The covariates of sex, ART, CD4+ T lymphocytes and viral load were obtained through questionnaires and medical records. Sexual maturation was self-reported and physical activity was measured using accelerometers. Simple and multiple linear regression were used, with P < 0.05.
RESULTS
HGS was directly associated with subtotal BMD (β = 0.002; R² = 0.670; P < 0.001), subtotal BMC (β = 0.090; R² = 0.734; P = 0.005) and lumbar-spine BMC (β = 1.004; R² = 0.656; P = 0.010) in the adjusted analyses. However, no significant association was found between HGS and lumbar-spine BMD (β = 0.001; R² = 0.464; P = 0.299).
CONCLUSION
HGS was directly associated with BMD and BMC in HIV-infected children and adolescents.
背景
在人类免疫缺陷病毒（HIV）感染的儿童和青少年中，已经发现骨矿物质含量（BMC）和骨矿物质密度（BMD）较低。HIV 感染和联合抗逆转录病毒治疗（ART）的直接不良影响对骨代谢有负面影响。在 HIV 感染的成年人和老年人中，已经描述了肌肉力量水平与 BMD 之间的直接关系。然而，尚不清楚 HANDGRIP 强度（HGS）是否与诊断为 HIV 的儿科人群的骨量有关。
目的
确定 HGS 水平是否与 HIV 感染的儿童和青少年的 BMC 和 BMD 相关。
设计和设置
2016 年在巴西弗洛里亚诺波利斯进行的横断面研究。
方法
研究对象为 65 名经垂直传播诊断为 HIV 的儿童和青少年（8-15 岁）。通过双能 X 射线吸收法（DXA）获得总骨量和腰椎 BMC 和 BMD。使用手动测力计测量 HGS。通过问卷和病历获得性别的、ART、CD4+T 淋巴细胞和病毒载量的协变量。性成熟是自我报告的，体力活动是通过加速度计测量的。采用简单和多元线性回归，P<0.05。
结果
在调整后的分析中，HGS 与总骨密度（β=0.002；R²=0.670；P<0.001）、总 BMC（β=0.090；R²=0.734；P=0.005）和腰椎 BMC（β=1.004；R²=0.656；P=0.010）呈直接相关。然而，HGS 与腰椎 BMD 之间没有显著关联（β=0.001；R²=0.464；P=0.299）。
结论
HGS 与 HIV 感染的儿童和青少年的 BMD 和 BMC 直接相关。
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