Chen Yvonne Y, Aponik-Gremillion Lyndsey, Bartoli Eleonora, Yoshor Daniel, Sheth Sameer A, Foster Brett L
Department of Neurosurgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Department of Neurosurgery, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Cell Rep. 2021 Jun 29;35(13):109304. doi: 10.1016/j.celrep.2021.109304.
High-frequency activity bursts in the hippocampus, known as ripples, are thought to support memory consolidation during "offline" states, such as sleep. Recently, human hippocampal ripples have been observed during "online" episodic memory tasks. It remains unclear whether similar ripple activity occurs during other cognitive states, including different types of episodic memory. However, identifying genuine ripple events in the human hippocampus is challenging. To address these questions, spectro-temporal ripple identification was applied to human hippocampal recordings across a variety of cognitive tasks. Overall, ripple attributes were stable across tasks of visual perception and associative memory, with mean rates lower than offline states of rest and sleep. In contrast, while more complex visual attention tasks did not modulate ripple attributes, rates were enhanced for more complex autobiographical memory conditions. Therefore, hippocampal ripples reliably occur across cognitive states but are specifically enhanced during offline states and complex memory processes, consistent with a role in consolidation.
海马体中的高频活动爆发，即所谓的涟漪，被认为在睡眠等“离线”状态下支持记忆巩固。最近，在“在线”情景记忆任务期间观察到了人类海马体的涟漪。目前尚不清楚在包括不同类型情景记忆在内的其他认知状态下是否会发生类似的涟漪活动。然而，识别人类海马体中真正的涟漪事件具有挑战性。为了解决这些问题，将频谱-时间涟漪识别应用于各种认知任务中的人类海马体记录。总体而言，在视觉感知和联想记忆任务中，涟漪属性是稳定的，平均发生率低于休息和睡眠的离线状态。相比之下，虽然更复杂的视觉注意力任务没有调节涟漪属性，但在更复杂的自传体记忆条件下发生率会提高。因此，海马体涟漪在各种认知状态下都可靠地发生，但在离线状态和复杂记忆过程中会特别增强，这与巩固作用一致。
